Abstract
We present an extremely rare case of a benign cystic ovarian teratoma with structures of male accessory sexual glands. The patient was a 30-year-old woman. A unilocular cystic tumor, measuring 5cm in the largest diameter, was found in her right ovary and was removed. The teratoma contained epidermis, skin appendages, respiratory and intestinal epithelia, cartilage, muscle, and nervous and connective tissue. In addition to these histologically mature tissues, there were nodules with prostatic acini, prostate duct-like structures strongly positive for prostate-specific antigen and acid prostatic phosphatase, structures resembling Cowper’s glands, and seminal vesicles surrounded by fibromuscular stroma. To our knowledge, this is the first case in the English literature describing seminal vesicles associated with prostatic tissue and bulbo-urethral glands in a mature ovarian teratoma.
Similar content being viewed by others
References
Bertrand GM (1986) Unique finding of prostatic tissue in a benign cystic ovarian teratoma. Arch Pathol Lab Med 110:683–684
Brumback RA, Brown BS, di Sant’Agnese PA (1985) Unique finding of prostatic tissue in a benign cystic ovarian teratoma. Arch Pathol Lab Med 109:675–677
Halabi M, Oliva E, Mazal PR, Breitenecker G, Young RH (2002) Prostatic tissue in mature cystic teratomas of the ovary: a report of four cases, including one with features of prostatic adenocarcinoma, and cytogenetic studies. Int J Gynecol Pathol 21:261–267
Kim KR, Park KH, Kim JW, Cho KJ, Ro JY (2004) Transitional cell metaplasia and ectopic prostatic tissue in the uterine cervix and vagina in a patient with adrenogenital syndrome: report of a case suggesting a possible role of androgen in the histogenesis. Int J Gynecol Pathol 23:182–187
McCluggage WG, Ganesan R, Hirschowitz L, Miller K, Rollason TP (2006) Ectopic prostatic tissue in the uterine cervix and vagina: report of a series with a detailed immunohistochemical analysis. Am J Surg Pathol 30:209–215
McLachlin CM, Srigley JR (1992) Prostatic tissue in mature cystic teratomas of the ovary. Am J Surg Pathol 16:780–784
Melniker LA, Slavutin LJ (1980) Prostatic tissue in a benign cystic teratoma of the ovary. Diagn Gynecol Obstet 2:139–145
Nogales FF, Vergara E, Medina MT (1995) Prostate in ovarian mature cystic teratoma. Histopathology 26:373–375
Resta L, Marzullo A, Pellegrino M, Rizzi E, Piscitelli D (2004) Male urogenital sinus structures in mature cystic teratomas of the ovary. Report of two cases. Histopathology 45:303–305
Smith CE, Toplis PJ, Nogales FF (1999) Ovarian prostatic tissue originating from hilar mesonephric rests. Am J Surg Pathol 23:232–236
Uzoaru I, Nadimpalli V (1993) Prostate in ovarian teratoma. Am J Surg Pathol 17:531
Vadmal M, Steven I (1996) Prostatic tissue in cystic ovarian teratomas. Hum Pathol 27:428–429
Conflict of interest statement
We declare that we have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Shelekhova, K.V., Hejda, V., Kazakov, D.V. et al. Mature cystic teratoma of the ovary with male accessory sexual glands including seminal vesicles, prostatic tissue, and bulbo-urethral glands: a case report. Virchows Arch 452, 109–111 (2008). https://doi.org/10.1007/s00428-007-0546-9
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00428-007-0546-9