Abstract
In this report, a rare renal tumor that morphologically resembles a thyroid follicular carcinoma is described. To date, this subtype has not been integrated into a known form of renal carcinoma. A 29-year-old female patient without relevant family or social history underwent nephrectomy because of a renal tumor measuring 5 cm by the largest diameter. The macroscopically white-yellow tumor showed follicular structures with abundant eosinophilic colloidal material and focal papillary differentiation by light microscopy. Immunohistochemically, the tumor cells stained positively for cytokeratin (CK-7, CK-20, CAM 5.2) and vimentin. CD-10, CD-117, thyroid transcription factor-1, and thyreoglobulin remained completely negative. Chromosomal losses of 1, 3, 7, 9p21, 12, 17, and X were detected by fluorescence in situ hybridization. Scintigraphs showed an inconspicuous thyroid gland and no extrathyroidal pathological accumulations, making metastatic spread to the kidney highly unlikely. To our knowledge, this is the second fully documented case of a thyroid follicular carcinoma-like renal tumor. This uncommon variant is important to keep in mind to prevent unnecessary or inappropriate treatment.
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Bazille C, Allory Y, Molinie V, Vieillefond A, Cochand-Priollet B, Cussenot O, Callard P, Sibony M (2004) Immunohistochemical characterisation of the main histologic subtypes of epithelial renal tumours on tissue-microarrays. Study of 310 cases. Ann Pathol 24:395–406
Berghella V, Ngadiman S, Rosenberg H, Hoda S, Zuna RE (1997) Malignant struma ovarii. A case report and review of the literature. Gynecol Obstet Invest 43:68–72
Cao Y, Paner GP, Perry KT, Flanigan RC, Campbell SC, Picken MM (2005) Renal neoplasms in younger adults: analysis of 112 tumors from a single institution according to the new 2004 World Health Organization classification and 2002 American Joint Committee on Cancer Staging System. Arch Pathol Lab Med 129:487–491
Chung JK, So Y, Lee JS, Choi CW, Lim SM, Lee DS, Hong SW, Youn YK, Lee MC, Cho BY (1999) Value of FDG PET in papillary thyroid carcinoma with negative 131I whole-body scan. J Nucl Med 40:986–992
Dai L, Lu XH, Li ZH, Li R, Liu H, Liu YL, Hui YZ (2004) Value of special stains and immunohistochemistry in the diagnosis of renal epithelial neoplasms. Zhonghua Bing Li Xue Za Zhi 33:140–142
de Micco C, Ruf J, Carayon P, Chrestian MA, Henry JF, Toga M (1987) Immunohistochemical study of thyroglobulin in thyroid carcinomas with monoclonal antibodies. Cancer 59:471–476
Devaney K, Snyder R, Norris HJ, Tavassoli FA (1993) Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. Int J Gynecol Pathol 12:333–343
Fumarola A, Trimboli P, Cavaliere R, Coletta I, Veltri A, Di Fiore A, Ciardi A, Piccirilli F (2006) Thyroid papillary carcinoma arising in ectopic thyroid tissue within a neck branchial cyst. World J Surg Oncol 4:24
Gonzalez-Angulo A, Kaufman RH, Braungard CD, Chapman FC, Hinshaw AJ (1963) Adenocarcinoma of thyroid arising in struma ovarii (malignant struma ovarii). Report of two cases and review of the literature. Obstet Gynecol 21:567–576
Harach HR, Franssila KO (1988) Thyroglobulin immunostaining in follicular thyroid carcinoma: relationship to the degree of differentiation and cell type. Histopathology 13:43–54
Hasleton PS, Kelehan P, Whittaker JS, Burslem RW, Turner L (1987) Benign and malignant struma ovarii. Arch Pathol Lab Med 102:180–184
Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ (2007) Cancer statistics, 2007. CA Cancer J Clin 57:43–66
Jung SJ, Chung JI, Park SH, Ayala AG, Ro JY (2006) Thyroid follicular carcinoma-like tumor of kidney: a case report with morphologic, immunohistochemical, and genetic analysis. Am J Surg Pathol 30:411–415
Junker K, Schlichter A, Junker U, Knofel B, Kosmehl H, Schubert J, Claussen U (1997) Cytogenetic, histopathologic, and immunologic studies of multifocal renal cell carcinoma. Cancer 79:975–981
Kim MK, Kim S (2002) Immunohistochemical profile of common epithelial neoplasms arising in the kidney. Appl Immunohistochem Mol Morphol 10:332–338
Kosary CL, McLaughlin JK (1993) Kidney and renal pelvis. In: Miller BA, Ries LAG, Hankey BF et al (eds) SEER cancer statistics review. 1973–1990. NIH publication no. 93-2789, XI.1-XI.22. National Cancer Institute, Bethesda, MD
Kovacs G (1993) Molecular cytogenetics of renal cell tumors. Adv Cancer Res 62:89–124
Lau LC, Tan PH, Chong TW, Foo KT, Yip S (2007) Cytogenetic alterations in renal tumors: a study of 38 Southeast Asian patients. Cancer Genet Cytogenet 175:1–7
Ling L, Zhou SH, Wang SQ, Wang LJ (2004) Misdiagnosed ectopic thyroid carcinoma: report of two cases. Chin Med J (Engl) 117:1588–1589
Miettinen M, Franssila KO (2000) Variable expression of keratins and nearly uniform lack of thyroid transcription factor 1 in thyroid anaplastic carcinoma. Human Pathol 31:1139–1145
Nieminen U, Vonnumers C, Widholm O (1964) Struma ovarii acta. Obstet Gynecol Scand 42:399–424
Pacini F, Molinaro E, Lippi F, Castagna MG, Agate L, Ceccarelli C, Taddei D, Elisei R, Capezzone M, Pinchera A (2001) Prediction of disease status by recombinant human TSH-stimulated serum Tg in the postsurgical follow-up of differentiated thyroid carcinoma. J Clin Endocrinol Metab 86:5686–5690
Pardo-Mindan FJ, Vazquez JJ (1983) Malignant struma ovarii. Light and electron microscopic study. Cancer 51:337–343
Ratnatnga N, Ramadasa S (1993) Immunohistochemical staining for thyroglobulin in poorly differentiated carcinoma of the thyroid. Ceylon Med J 38:113–116
Receveur AO, Couturier J, Molinie V, Vieillefond A, Desangles F, Guillaud-Bataille M, Danglot G, Coullin P, Bernheim A (2005) Characterization of quantitative chromosomal abnormalities in renal cellcarcinomas by interphase four-color fluorescence in situ hybridization. Cancer Genet Cytogenet 158:110–118
Reuter VE, Presti JC Jr (2000) Contemporary approach to the classification of renal epithelial tumors. Semin Oncol 27:124–137
Speicher MR, Schoell B, du Manoir S, Schrock E, Ried T, Cremer T, Storkel S, Kovacs A, Kovacs G (1994) Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am J Pathol 145:356–364
Verdorfer I, Hobisch A, Hittmair A, Duba HC, Bartsch G, Utermann G, Erdel M (1999) Cytogenetic characterization of 22 human renal cell tumors in relation to a histopathological classification. Cancer Genet Cytogenet 111:61–70
Woodruff JD, Rauh JT, Markley RL (1966) Ovarian struma. Obstet Gynecol 27:94–201
Yannopoulos D, Yannopoulos K, Ossowski R (1976) Malignant struma ovarii. Pathol Annu 11:403–413
Yildiz K, Koksal H, Ozoran Y, Muhtar H, Telatar M (1993) Papillary carcinoma in a thyroglossal duct remnant with normal thyroid gland. J Laryngol Otol 107:1174–1176
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An erratum to this article can be found at http://dx.doi.org/10.1007/s00428-008-0600-2
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William, S., Irmgard, V., Michael, G. et al. Thyroid follicular carcinoma-like renal tumor: a case report with morphologic, immunophenotypic, cytogenetic, and scintigraphic studies. Virchows Arch 452, 91–95 (2008). https://doi.org/10.1007/s00428-007-0486-4
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DOI: https://doi.org/10.1007/s00428-007-0486-4