Skip to main content

Advertisement

SpringerLink
Log in

Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature

  • Original Article
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade sarcoma of the distal extremities characterized by a myxohyaline stroma, a dense inflammatory infiltrate and virocyte- and lipoblast-like giant cells. Up to now, only two cases have been investigated cytogenetically, showing complex and heterogeneous karyotypes, in part with supernumerary ring chromosomes. We characterized two further cases of MIFS immunohistochemically and performed comparative genomic hybridization as well as DNA image cytometry analyses. Both tumors showed the characteristic histomorphological pattern of MIFS and were positive for Vimentin and CD68. Moreover, both cases presented aberrant karyotypes including distinct DNA copy number changes involving chromosome 7 and disclosed DNA aneuploidy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Ebhardt H, Kosmehl H, Katenkamp D (2001) Acral myxoinflammatory fibroblastic sarcoma. Six cases of a tumor entity. Pathologe 22:157–161

    Article  PubMed  CAS  Google Scholar 

  2. Fletcher C, Unni K, Mertens F (2002) World Health Organization classification of tumours: pathology and genetics of tumours of soft tissue and bone. IARC, Lyon, France

    Google Scholar 

  3. Giroud F, Haroske G, Reith A, Bocking A (1998) 1997 ESACP consensus report on diagnostic DNA image cytometry. Part II: specific recommendations for quality assurance. European Society for Analytical Cellular Pathology. Anal Cell Pathol 17:201–208

    PubMed  CAS  Google Scholar 

  4. Haroske G, Giroud F, Reith A, Bocking A (1998) 1997 ESACP consensus report on diagnostic DNA image cytometry. Part I: basic considerations and recommendations for preparation, measurement and interpretation. European Society for Analytical Cellular Pathology. Anal Cell Pathol 17:189–200

    PubMed  CAS  Google Scholar 

  5. Haroske G, Meyer W, Theissig F, Schubert K, Kunze KD (1998) Remote quantitation server for quality assurance in DNA ploidy analysis. Anal Quant Cytol Histol 20:302–312

    PubMed  CAS  Google Scholar 

  6. Jurcic V, Zidar A, Montiel MD, Frkovic-Grazio S, Nayler SJ, Cooper K et al (2002) Myxoinflammatory fibroblastic sarcoma: a tumor not restricted to acral sites. Ann Diagn Pathol 6:272–280

    Article  PubMed  Google Scholar 

  7. Kallioniemi OP, Kallioniemi A, Piper J, Isola J, Waldman FM, Gray JW et al (1994) Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosomes Cancer 10:231–243

    Article  PubMed  CAS  Google Scholar 

  8. Kinkor Z, Mukensnabl P, Michal M (2002) Inflammatory myxohyaline tumor with massive emperipolesis. Pathol Res Pract 198:639–642

    Article  PubMed  Google Scholar 

  9. Lambert I, Debiec-Rychter M, Guelinckx P, Hagemeijer A, Sciot R (2001) Acral myxoinflammatory fibroblastic sarcoma with unique clonal chromosomal changes. Virchows Arch 438:509–512

    Article  PubMed  CAS  Google Scholar 

  10. Lang JE, Dodd L, Martinez S, Brigman BE (2006) Case reports: acral myxoinflammatory fibroblastic sarcoma: a report of five cases and literature review. Clin Orthop Relat Res 445:254–260

    PubMed  Google Scholar 

  11. Mansoor A, Fidda N, Himoe E, Payne M, Lawce H, Magenis RE (2004) Myxoinflammatory fibroblastic sarcoma with complex supernumerary ring chromosomes composed of chromosome 3 segments. Cancer Genet Cytogenet 152:61–65

    Article  PubMed  CAS  Google Scholar 

  12. Meis-Kindblom JM, Kindblom LG (1998) Acral myxoinflammatory fibroblastic sarcoma: a low-grade tumor of the hands and feet. Am J Surg Pathol 22:911–924

    Article  PubMed  CAS  Google Scholar 

  13. Michal M (1998) Inflammatory myxoid tumor of the soft parts with bizarre giant cells. Pathol Res Pract 194:529–533

    PubMed  CAS  Google Scholar 

  14. Montgomery EA, Devaney KO, Giordano TJ, Weiss SW (1998) Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin’s disease, and various sarcomas. Mod Pathol 11:384–391

    PubMed  CAS  Google Scholar 

  15. Oda Y, Tamiya S, Oshiro Y, Hachitanda Y, Kinukawa N, Iwamoto Y et al (2002) Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts. Pathol Int 52:595–606

    Article  PubMed  Google Scholar 

  16. Pohar-Marinsek Z, Flezar M, Lamovec J (2003) Acral myxoinflammatory fibroblastic sarcoma in FNAB samples: can we distinguish it from other myxoid lesions? Cytopathology 14:73–78

    Article  PubMed  CAS  Google Scholar 

  17. Sakaki M, Hirokawa M, Wakatsuki S, Sano T, Endo K, Fujii Y et al (2003) Acral myxoinflammatory fibroblastic sarcoma: a report of five cases and review of the literature. Virchows Arch 442:25–30

    PubMed  Google Scholar 

  18. Weiss SW, Goldblum JR (2001) Enzinger and Weiss’s soft tissue tumors. Mosby, St. Louis, Missouri, USA

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pathology, University of Basel, Schönbeinstrasse 40, 4003, Basel, Switzerland

    Daniel Baumhoer, Kathrin Glatz, Martin Oberholzer & Gernot Jundt

  2. Bone Tumor Reference Center at the Institute of Pathology, University of Basel, 4003, Basel, Switzerland

    Gernot Jundt

  3. Department of Pathology, University of Göttingen, 37099, Göttingen, Germany

    Hans-Jürgen Schulten & László Füzesi

  4. Department of Surgery, Kantonsspital Bruderholz, 4101, Bruderholz, Switzerland

    Renato Fricker

  5. Department of Surgery, University of Basel, 4003, Basel, Switzerland

    Christoph Kettelhack

  6. Department of Surgery, Bethesda Spital, 4020, Basel, Switzerland

    Paula Hasenboehler

Authors
  1. Daniel Baumhoer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kathrin Glatz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hans-Jürgen Schulten
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. László Füzesi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Renato Fricker
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Christoph Kettelhack
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Paula Hasenboehler
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Martin Oberholzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Gernot Jundt
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel Baumhoer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baumhoer, D., Glatz, K., Schulten, HJ. et al. Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature. Virchows Arch 451, 923–928 (2007). https://doi.org/10.1007/s00428-007-0480-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-007-0480-x

Keywords

Search

Navigation