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Primary mediastinal anaplastic alk-1-positive large-cell lymphoma of T/NK-cell type expressing CD20

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Abstract

We describe an unusual case of ALK-1-positive primary mediastinal lymphoma with the morphology of an anaplastic large-cell lymphoma (ALCL) of T/NK cell type but expressing CD20. This tumour had T/NK morphology and immunophenotype, as demonstrated by its expression of CD30, EMA, ALK-1, CD7 and TiA-1 and the lack of expression of B-cell markers other than CD20. The significance of such a co-expression of a B cell-associated antigen in a case of ALCL of T/NK cell type is discussed.

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Authors and Affiliations

  1. Service Central d’Anatomie et Cytologie Pathologiques, “Jacques Delarue”, Hôtel-Dieu, 1, place du parvis Notre-Dame, 75181, Paris Cedex 04, France

    J. Gonin, H. Kadiri, A. Le Tourneau, T. J. Molina, J. Diebold & J. Audouin

  2. Département de pathologie, Centre Hospitalier, Sétif, Algéria

    S. Bensaci & D. J. Abdellouche

Authors
  1. J. Gonin
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  2. H. Kadiri
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  3. S. Bensaci
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  4. A. Le Tourneau
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  5. T. J. Molina
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  6. J. Diebold
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  7. D. J. Abdellouche
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  8. J. Audouin
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Correspondence to J. Diebold.

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Gonin, J., Kadiri, H., Bensaci, S. et al. Primary mediastinal anaplastic alk-1-positive large-cell lymphoma of T/NK-cell type expressing CD20. Virchows Arch 450, 355–358 (2007). https://doi.org/10.1007/s00428-007-0371-1

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  • DOI: https://doi.org/10.1007/s00428-007-0371-1

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