Abstract
A 17-year-old man was treated with chemotherapy and radiation for nodular sclerosing Hodgkin lymphoma that presented as a left chest wall mass. Ten years later, a left upper lobe lung tumor was identified. The tumor resection demonstrated a 1.3-cm yellow lung nodule composed of epithelioid and spindled lipid-laden CD68+ and Factor XIIIa+ macrophages. Distinct follicular structures with dendritic cells positive for CD1a, fascin, and ALK-1 and largely devoid of intracytoplasmic lipid were a distinguishing feature of the lesion. Most of the xanthomatous macrophages expressed human herpes virus-8 antigen. The current World Health Organization classification of “inflammatory myofibroblastic tumors” is examined, and the association of a subset of “inflammatory pseudotumors” with immunodeficiency states and opportunistic infection is discussed.
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Funding was provided by the Massachusetts General Hospital Pathology Service James Homer Wright Pathology Laboratories. The experiments performed comply with the current laws of the United States of America.
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Farris, A.B., Kradin, R.L. Follicular localization of dendritic cells in a xanthomatous inflammatory tumor of lung associated with human herpes virus-8 infection. Virchows Arch 449, 726–729 (2006). https://doi.org/10.1007/s00428-006-0318-y
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DOI: https://doi.org/10.1007/s00428-006-0318-y