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Immunohistochemical localization of the NM23 protein in salivary gland neoplasms with distinct biological behavior

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Abstract

The NM23 protein was shown to be associated with metastasis suppression in human malignancies with various tissue origins. However, its association with the metastatic phenotype of salivary gland neoplasms (SGN) remains unknown. To evaluate the role of NM23 in SGN, the expression patterns of NM23 in the following were compared: benign (pleomorphic adenoma) vs malignant (adenoid cystic carcinoma and mucoepidermoid carcinoma) SGN, and primary malignancies with/without evidence of metastasis vs their metastatic implants (MI). The lesions were studied immunohistochemically. NM23 protein was found in the cytoplasm of 75% of benign SGN, 73.3% of primary SGN malignancies with no evidence of metastasis, 86.6% of primary SGN malignancies with evidence of metastasis, and 60% of MI. There was no statistically significant difference in the frequency of NM23-positive cells between benign and primary malignant tumors (p = 0.79), nor between primary malignancies with/without evidence of metastasis and MI (p = 0.51). However, nuclear NM23 protein was restricted to primary SGN malignancies with evidence of metastasis and MI. The presence of nuclear NM23 protein may be a good marker for predicting the metastatic potential of SGN malignancies.

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Acknowledgments

This study was financially supported by the National Council for Research and Development (CNPq) and by the Research Supporting Foundation of Minas Gerais (FAPEMIG), Brazil.

The authors acknowledge Dr. Charles F. Shuler for the grammatical review.

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Authors and Affiliations

  1. Oral Pathology, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil

    Kelen Christine do Nascimento, Paulo Rogério de Faria, Sérgio Vitorino Cardoso & Adriano Mota Loyola

  2. Pathology, School of Medicine, Federal University of Triângulo Mineiro, Uberaba, Brazil

    Kelen Christine do Nascimento & Paulo Rogério de Faria

  3. Stomatology, School of Dentistry, Paulista University, São Paulo, Brazil

    Luciano Lauria Dib

  4. Oral Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Maria Cássia Ferreira de Aguiar

  5. Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA, 90033, USA

    Jucheng Chen

  6. Oral Pathology, School of Dentistry, Federal University of Uberlândia, Av. Pará, 1720 (2N/HC), CEP-38405-900, Uberlândia, Minas Gerais, Brazil

    Adriano Mota Loyola

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  1. Kelen Christine do Nascimento
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  2. Paulo Rogério de Faria
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  3. Luciano Lauria Dib
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  5. Sérgio Vitorino Cardoso
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  7. Adriano Mota Loyola
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Correspondence to Adriano Mota Loyola.

Additional information

The experimental analyses of this work were performed at the Oral Pathology Laboratory of the Federal University of Uberlândia, Brazil.

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do Nascimento, K.C., de Faria, P.R., Dib, L.L. et al. Immunohistochemical localization of the NM23 protein in salivary gland neoplasms with distinct biological behavior. Virchows Arch 449, 660–666 (2006). https://doi.org/10.1007/s00428-006-0280-8

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  • DOI: https://doi.org/10.1007/s00428-006-0280-8

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