Abstract
This report reviews the diagnostic and prognostic importance of the pathologic findings in prostate needle biopsies. The morphological findings of the needle biopsy may be placed into one of the following five categories: prostate cancer, atypical small acinar proliferation, high-grade prostatic intraepithelial neoplasia, inflammation, and benign prostatic tissue. While the prime goal of the biopsy is to diagnose prostatic adenocarcinoma, once carcinoma is detected, further descriptive information regarding the type, amount of cancer, and grade forms the cornerstone for contemporary management of the patient and for assessment of the potential for local cure and the risk for distant metastasis. The information provided in the needle biopsy report regarding the attributes of carcinoma is used depending on the individual patient’s medical condition and preference and on the treating physician’s evaluation to determine whether any form of treatment is indicated and, if so, the type of therapy.
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The publication of this paper is in part supported by a grant from the Italian Ministry of University and Scientific Research (RM) (MIUR 2003).
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Issues on the pathology reporting of prostate needle biopsies have been dealt with in recent consensus conferences organized under the auspices of the Uropathology Working Group (European Society of Pathology), European Society of Uropathology (a full section office member of the European Association of Urology) (Florence, Italy, June 2003, and Palermo, Sicily, June 2005), World Health Organization (Lyon, France, December 2002, and Stockholm, Sweden, September 2004), and International Society of Urologic Pathology (San Antonio, TX, USA, March 2005). The authors of this review have been involved in these conferences.
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Montironi, R., Vela Navarrete, R., Lopez-Beltran, A. et al. Histopathology reporting of prostate needle biopsies. 2005 update. Virchows Arch 449, 1–13 (2006). https://doi.org/10.1007/s00428-006-0190-9
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DOI: https://doi.org/10.1007/s00428-006-0190-9