Abstract
Follicular dendritic cell tumor (FDCT) is a rare tumor mainly located in laterocervical lymph nodes. We report one case of mediastinal FDCT associated with a history of bullous skin disease and clinically obvious immunosuppression. This tumor was characterized by heavy mast cell infiltration. Mast cells were in close relationship with tumor cells as demonstrated by ultrastructural examination and their presence are probably related with the strong expression of mast cell chemoattractants as fraktalkine and stromal cell-derived factor-1α by tumor cells. The long follow-up period of more than 17 years allowed to us assess the relatively indolent evolution of this tumor characterized by three slowly growing local recurrences without metastasis.
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Acknowledgements
The authors thank Prof. Thierry Molina from the Department of Pathology Hôtel-Dieu AP-HP Paris and Dr Agnès Carlotti from the Department of Pathology Paul Brousse Hospital AP-HP for helpful diagnostic discussions, and Ingrid Durand-Gasselin from Institut Paris-Sud sur les Cytokines Hôpital Antoine Béclère - Clamart for technical assistance.
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Guettier, C., Validire, P., Emilie, D. et al. Follicular dendritic cell tumor of the mediastinum: expression of fractalkine and SDF-1α as mast cell chemoattractants. Virchows Arch 448, 218–222 (2006). https://doi.org/10.1007/s00428-005-0143-8
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DOI: https://doi.org/10.1007/s00428-005-0143-8