Abstract
Nodular lymphoid lesion (NLL) of the liver is a rare but unique entity and has also been termed reactive lymphoid hyperplasia of the liver. We describe the histological, immunohistochemical and molecular biologic findings of a case with NLL and two other tumors of the liver. The nodular lymphoid mass found in the liver was composed of heterogeneous small lymphocytes forming reactive follicles. Plasma cells, few immunoblasts, centroblasts, few macrophages, epithelioid cells, and giant cells were seen. The lymphoid infiltrate displaced the adjacent hepatic parenchyma. By immunohistochemistry and molecular studies, the lymphocytes were found to be polyclonal. The diagnosis of NLL was made. In addition to NLL, focal nodular hyperplasia and hemangioma were detected. The discrimination of NLL from primary hepatic malignant non-Hodgkin’s lymphoma of mucosa- associated lymphoid tissue-type may pose diagnostic difficulties and may require the use of immunohistochemical and molecular techniques. The simultaneous occurrence of NLL with focal nodular hyperplasia and hemangioma in the liver has not been described before.
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Bronowicki JP, Bineau C, Feugier P, Hermine O, Brousse N, Oberti F, Rousselet MC, Dharancy S, Gaulard P, Flejou JF, Cazals-Hatem D, Labouyrie E (2003) Primary lymphoma of the liver: clinical-pathological features and relationship with HCV infection in French patients. Hepatology 37:781–787
Isaacson P, Müller-Hermelink HK, Piris MA, Berger F, Nathwani BN, Swerdlow SH, Harris NL (2001) Extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) World Health Organization Classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissue. IARC, Lyon, pp 157–160
Isaacson P, Wright DH (1984) Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer 53:2515–2524
Isaacson PG, Banks PM, Best PV, McLure SP, Müller-Hermelink HK, Wyatt JI (1995) Primary low-grade hepatic B cell lymphoma of mucosa-associated lymphoid tissue (MALT)-type. Am J Surg Pathol 19:571–575
Isobe H, Sakamoto S, Sakai H, Masumoto A, Sonoda T, Adachi E, Nawata H (1993) Reactive lymphoid hyperplasia of the liver. J Clin Gastroenterol 16:240–244
Katayanagi K, Terada T, Nakanuma Y, Ueno T (1994) A case of pseudolymphoma of the liver. Pathol Int 44:704–711
Kim SR, Hayashi Y, Kang KB, Soe CG, Kim JH, Yang MK, Itoh H (1997) A case of pseudolymphoma of the liver with chronic hepatitis C. J Hepatol 26:209–214
Kirk CM, Lewin D, Lazarchick J (1999) Primary hepatic B cell lymphoma of mucosa-associated lymphoid tissue. Arch Pathol Lab Med 123:716–719
Maes M, Depardieu C, Dargent JL, Hermans M, Verhaeghe JL, Delabie J, Pittaluga S, Troufleau P, Verhest A, De Wolf-Peeters C (1997) Primary low-grade B cell lymphoma of MALT-type occurring in the liver: a study of two cases. J Hepatol 27:922–927
Nagano K, Fukuda Y, Nakano I, Katano Y, Toyoda H, Nonami T, Nagasaka T, Hayakawa T (1999) Reactive lymphoid hyperplasia of liver coexisting with chronic thyroiditis: radiographical characteristics of the disorder. J Gastroenterol Hepatol 14:163–167
Ohtsu T, Sasaki Y, Tanizaki H, Kawano N, Ryu M, Satake M, Hasebe T, Mukai K, Fujikura M, Tamai M, et al (1994) Development of pseudolymphoma of liver following interferon-alpha therapy for chronic hepatitis B. Intern Med 33:18–22
Okubo H, Maekawa H, Ogawa K, Wada R, Sekigawa I, Iida N, Maekawa T, Hashimoto H, Sato N (2001) Pseudolymphoma of the liver associated with Sjogren’s syndrome. Scand J Rheumatol 30:117–119
Prabhu RM, Medeiros LJ, Kumar D, Drachenberg CI, Papadimitriou JC, Appelman HD, Johnson LB, Laurin J, Heyman M, Abruzzo LV (1998) Primary hepatic low-grade B cell lymphoma of mucosa-associated lymphoid tissue (MALT) associated with primary biliary cirrhosis. Mod Pathol 11:404–410
Schmitz D, Köhler HH, Heussel CP, Löhr HF, Galle PR (2001) Lymphoma-simulating presentation of focal nodular hyperplasia (FNH) of the liver. Z Gastroenterol 39:219–224
Sharifi S, Murphy M, Loda M, Pinkus GS, Khettry U (1999) Nodular lymphoid lesion of the liver: an immune-mediated disorder mimicking low-grade malignant lymphoma. Am J Surg Pathol 23:302–308
Tanizawa T, Eishi Y, Kamiyama R, Nakahara M, Abo Y, Sumita T, Kawano N (1996) Reactive lymphoid hyperplasia of the liver characterized by an angiofollicular pattern mimicking Castleman’s disease. Pathol Int 46:782–786
van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, Garcia-Sanz R, van Krieken JH, Droese J, Gonzalez D, Bastard C, White HE, Spaargaren M, Gonzalez M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17:2257–2317
Ye MQ, Suriawinata A, Black C, Min AD, Strauchen J, Thung SN (2000) Primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type in a patient with primary biliary cirrhosis. Arch Pathol Lab Med 124:604–608
Zucca E, Conconi A, Pedrinis E, Cortelazzo S, Motta T, Gospodarowicz MK, Patterson BJ, Ferreri AJM, Ponzoni M, Devizzi L, Giardini R, Pinotti G, Capella C, Zinzani PL, Pileri S, Lopez-Guillermo A, Campo E, Ambrosetti A, Baldini L, Cavalli F (2003) Nongastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue. Blood 101:2489–2495
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Willenbrock, K., Kriener, S., Oeschger, S. et al. Nodular lymphoid lesion of the liver with simultaneous focal nodular hyperplasia and hemangioma: discrimination from primary hepatic MALT-type non-Hodgkin’s lymphoma. Virchows Arch 448, 223–227 (2006). https://doi.org/10.1007/s00428-005-0126-9
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DOI: https://doi.org/10.1007/s00428-005-0126-9