Virchows Archiv

, Volume 448, Issue 1, pp 100–104 | Cite as

Sudden infant death syndrome (SIDS) shortly after hexavalent vaccination: another pathology in suspected SIDS?

  • Giulia Ottaviani
  • Anna Maria Lavezzi
  • Luigi MatturriEmail author
Case Report


Experts from panels of the European Agency for the Evaluation of Medical Products have investigated whether there might be a link between hexavalent vaccines and some cases of deaths that occurred. Participants included pathologists with experience in the field of vaccines and sudden infant death syndrome who conducted autopsies. However, to the best of our knowledge, little, if any, attention was paid to examination of the brainstem and the cardiac conduction systems on serial sections, nor was the possibility of a triggering role of the vaccine in these deaths considered. Herein we report the case of a 3-month-old female infant dying suddenly and unexpectedly shortly after being given a hexavalent vaccination. Examination of the brainstem on serial sections revealed bilateral hypoplasia of the arcuate nucleus. The cardiac conduction system presented persistent fetal dispersion and resorptive degeneration. This case offers a unique insight into the possible role of hexavalent vaccine in triggering a lethal outcome in a vulnerable baby. Any case of sudden unexpected death occurring perinatally and in infancy, especially soon after a vaccination, should always undergo a full necropsy study according to our guidelines.


Sudden infant death SIDS Hexavalent vaccine Arcuate nucleus hypoplasia Cardiac conduction system Prolonged external cardiac massage 



The authors wish to express their gratitude to Mrs. Graziella Alfonsi for skillful technical cooperation.

This study was supported by the “Lino Rossi” Research Center for the study and prevention of unexpected perinatal death and sudden infant death syndrome (SIDS) funding (Rectorial Decree no. 225678 of 23/04/04) and by the Ministry of Foreign Affairs (joint project of particular relevance no. 269/P/0085087, “Anatomopathologic and genetic study of the unexplained perinatal death and SIDS”), Italy.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Giulia Ottaviani
    • 1
  • Anna Maria Lavezzi
    • 1
  • Luigi Matturri
    • 1
    Email author
  1. 1.Institute of PathologyUniversity of MilanMilanItaly

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