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Growth pattern and distribution of follicular dendritic cells in mantle cell lymphoma: a clinicopathological study of 96 patients

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Abstract

Mantle cell lymphoma (MCL) is an aggressive lymphoma with accepted risk factors such as proliferation markers. To date, the different follicular dendritic cell (FDC) patterns have never been analyzed in comparison with the overall survival time. Lymph node biopsy specimens from 96 patients were analyzed by conventional morphology and immunohistochemistry with antibodies against cluster differentiation (CD)20, CD5, CD23, cyclin D1, and FDC (Ki-M4P). Two groups can be distinguished with different FDC patterns: a nodular pattern in 79 cases and a diffuse pattern in 17 cases. A Kaplan–Meier analysis revealed significantly better survival for the nodular group (p=0.0312). This group was subdivided into a group with a nodular FDC pattern similar to the FDC distribution in primary follicles (PF-nodular in 72 cases) and one with a nodular FDC pattern resembling the colonization of germinal centers (GCs) by tumor cells (GC-nodular in seven cases). A Kaplan–Meier analysis showed that patients with MCL with a PF-nodular FDC pattern had a significantly better clinical outcome than patients with the other two patterns (p=0.0033). If only cases with classical cytology (n=79) were analyzed (blastoid types excluded), patients with a PF-nodular FDC pattern had a better clinical outcome (p=0.0008). The distribution of FDC in MCL is a diagnostic tool for identifying patients with a better clinical prognosis.

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Acknowledgements

We would like to thank Mrs. K. Dege for language editing and T. Zwingers (Estimate GmbH, Augsburg) for assistance with the statistical calculations.

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Authors and Affiliations

  1. II. Department of Internal Medicine and Hematology, University Hospital of Schleswig-Holstein, Kiel, Chemnitzstr. 33, 24116, Kiel, Germany

    Carsten Schrader

  2. Department of Hematopathology and Lymph Node Registry, University Hospital of Schleswig-Holstein, Kiel, Germany

    Carsten Schrader, Dirk Janssen, Reza Parwaresch & Markus Tiemann

  3. Division of Hematology, Department of Medicine, University of Duisburg-Essen, Duisburg-Essen, Germany

    Peter Meusers & Günter Brittinger

  4. Department of Otolaryngology, Head and Neck Surgery, University of Marburg, Marburg, Germany

    Afshin Teymoortash

  5. Department of General Surgery, University Hospital of Schleswig-Holstein, Kiel, Germany

    Jens U. Siebmann

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  1. Carsten Schrader
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Correspondence to Carsten Schrader.

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Schrader, C., Meusers, P., Brittinger, G. et al. Growth pattern and distribution of follicular dendritic cells in mantle cell lymphoma: a clinicopathological study of 96 patients. Virchows Arch 448, 151–159 (2006). https://doi.org/10.1007/s00428-005-0049-5

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