Virchows Archiv

, Volume 447, Issue 5, pp 794–799 | Cite as

Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study

  • Toru Furukawa
  • Günter Klöppel
  • N. Volkan Adsay
  • Jorge Albores-Saavedra
  • Noriyoshi Fukushima
  • Akira Horii
  • Ralph H. Hruban
  • Yo Kato
  • David S. Klimstra
  • Daniel S. Longnecker
  • Jutta Lüttges
  • G. Johan A. Offerhaus
  • Michio Shimizu
  • Makoto Sunamura
  • Arief Suriawinata
  • Kyoichi Takaori
  • Suguru Yonezawa
Original Article


Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological and immunohistochemical variations. At a meeting of international experts on pancreatic precursor lesions held in 2003, it was agreed that a consensus classification of IPMN subtypes should be established to enable a more detailed analysis of the clinicopathological significance of the variations. Based on our experience and on information from the literature, we selected representative histological examples of IPMNs and defined a consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type. These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN.


Pancreatic tumor Intraductal papillary-mucinous neoplasm Classification MUC 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Toru Furukawa
    • 1
  • Günter Klöppel
    • 2
  • N. Volkan Adsay
    • 3
  • Jorge Albores-Saavedra
    • 4
  • Noriyoshi Fukushima
    • 5
  • Akira Horii
    • 1
  • Ralph H. Hruban
    • 6
  • Yo Kato
    • 7
  • David S. Klimstra
    • 8
  • Daniel S. Longnecker
    • 9
  • Jutta Lüttges
    • 2
  • G. Johan A. Offerhaus
    • 10
  • Michio Shimizu
    • 11
  • Makoto Sunamura
    • 12
  • Arief Suriawinata
    • 9
  • Kyoichi Takaori
    • 13
  • Suguru Yonezawa
    • 14
  1. 1.Department of Molecular PathologyTohoku University School of MedicineSendaiJapan
  2. 2.Department of PathologyUniversity of KielKielGermany
  3. 3.Department of PathologyWayne State UniversityDetroitUSA
  4. 4.Department of PathologyLSU Health Sciences CenterShreveportUSA
  5. 5.Department of PathologyTokyo Medical CollegeTokyoJapan
  6. 6.Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research CenterThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  7. 7.Department of Pathology, Cancer InstituteJapanese Foundation for Cancer ResearchTokyoJapan
  8. 8.Department of PathologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  9. 9.Department of PathologyDartmouth-Hitchcock Medical CenterLebanonUSA
  10. 10.Department of PathologyAcademic Medical CenterAmsterdamThe Netherlands
  11. 11.Department of PathologySaitama Medical SchoolSaitamaJapan
  12. 12.Department of Gastroenterological SurgeryTohoku University School of MedicineSendaiJapan
  13. 13.Department of General and Gastroenterological SurgeryOsaka Medical CollegeOsakaJapan
  14. 14.Department of Human Pathology, Field of OncologyKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan

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