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Cytogenetic analysis of myoepithelial cell carcinoma of salivary gland

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Abstract

Myoepithelial cell carcinoma (MCC) of the salivary gland is a rare entity. Here, we describe the karyotype of MCC. The patient was a 53-year-old man, with a rapidly growing lesion of the palate. Despite complete surgical excision, radio- and chemotherapy, the lesion rapidly harboured local and distant metastases leading to the death of the patient, 4 months after the diagnosis. On histological and ultrastructural examination, the primary tumour and the related metastases were composed of oval and spindle cells, with features of myoepithelial cell differentiation reported in the literature. Cytogenetic analysis showed a composite karyotype in the primary tumour: 45~46,XY, +3[cp3]/ 44~45,XY, -17[cp4]/ 46,XY[5]. The lymph-node metastasis was near-triploid and showed a complex karyotype. Our cytogenetic data differ from those described in benign or slowly growing salivary gland tumours showing myoepithelial cell differentiation. It is suggested that highly aggressive tumours might follow a different pathway of malignant transformation.

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Acknowledgements

Prof. Vincenzo Eusebi is thanked for having critically reviewed the paper, Mrs. Luciana Muzzi for technical help. The study has been supported by grants from the University of Bologna.

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Authors and Affiliations

  1. Anatomia Patologica, Università di Bologna, Ospedale Bellaria, Via Altura 3, 40139 , Bologna, Italy

    Elisabetta Magrini, Anna Farnedi & Maria P. Foschini

  2. Department of Maxillo-Facial Surgery, Ospedale Bellaria, Bologna, Italy

    Roberto Cocchi

  3. Anatomic Pathology, Ospedale Bufalini, Cesena, Italy

    Antonella Pragliola

  4. Department of Experimental Pathology, University of Bologna, Italy

    Christine M. Betts

Authors
  1. Elisabetta Magrini
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  2. Antonella Pragliola
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  3. Anna Farnedi
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  4. Christine M. Betts
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  5. Roberto Cocchi
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  6. Maria P. Foschini
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Corresponding author

Correspondence to Maria P. Foschini.

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Magrini, E., Pragliola, A., Farnedi, A. et al. Cytogenetic analysis of myoepithelial cell carcinoma of salivary gland. Virchows Arch 444, 82–86 (2004). https://doi.org/10.1007/s00428-003-0909-9

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  • DOI: https://doi.org/10.1007/s00428-003-0909-9

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