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Expression of cyclooxygenase-2 in chondroblastoma: immunohistochemical analysis with special emphasis on local inflammatory reaction

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Abstract

To investigate the frequency and mechanism of the peritumoral inflammatory reaction in chondroblastoma, we evaluated the relationship between clinicoradiological findings and immunohistochemical expression of cyclooxygenase-2 (COX-2) in excised tumors. Twenty-one cases of chondroblastoma were studied. Imaging analysis was performed with radiographs and T1- and T2-weighted magnetic resonance images in all cases and with computed tomography scan and bone scintigraphy in some cases. Immunohistochemical study for COX-2 was carried out using formalin-fixed paraffin-embedded tissues. Periosteal reaction was observed in 6 cases (29%) and bone marrow edema in 15 cases (71%). Soft-tissue edema, joint effusion, and synovitis were found in 10 cases (48%), in 7 cases (33%), and in 9 cases (43%), respectively. Immunohistochemical expression of COX-2 in chondroblastoma cells was found in 15 of 21 cases (71%). The intensity of COX-2 immunoreactivity was correlated statistically with the presence of periosteal reaction, bone-marrow edema, soft-tissue edema, and synovitis. Our results indicate that activation of eicosanoid synthesis by COX-2 expression in the tumor itself is probably an important factor, inducing peritumoral inflammatory changes in chondroblastomas.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Tokyo Medical University, Nishishinjuku 6-7-1, Shinjuku-ku, 160-0013, Tokyo , Japan

    Koutaro Shinmura, Hiroyuki Hattori, Shuzou Nagai & Atsuhiro Imakiire

  2. First Department of Pathology, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku-ku, 160-8402, Tokyo , Japan

    Tsuyoshi Ishida, Masahiko Kuroda & Kiyoshi Mukai

  3. Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo , Japan

    Takahiro Goto

  4. Department of Surgical Pathology, Teikyo University School of Medicine, Kaga 2-11-1, Itabashi-ku, 173-8605, Tokyo , Japan

    Tetsuo Imamura

  5. First Department of Pathology, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku-ku, 160-8402, Tokyo , Japan

    Tsuyoshi Ishida

Authors
  1. Koutaro Shinmura
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  2. Tsuyoshi Ishida
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  3. Takahiro Goto
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  4. Masahiko Kuroda
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  5. Hiroyuki Hattori
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  6. Shuzou Nagai
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  7. Tetsuo Imamura
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  8. Kiyoshi Mukai
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  9. Atsuhiro Imakiire
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Correspondence to Tsuyoshi Ishida.

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Shinmura, K., Ishida, T., Goto, T. et al. Expression of cyclooxygenase-2 in chondroblastoma: immunohistochemical analysis with special emphasis on local inflammatory reaction. Virchows Arch 444, 28–35 (2004). https://doi.org/10.1007/s00428-003-0889-9

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  • DOI: https://doi.org/10.1007/s00428-003-0889-9

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