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Lipoblastoma in a 23-year-old male: distinction from atypical lipomatous tumor using cytogenetic and fluorescence in-situ hybridization analysis

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Abstract

Lipoblastoma is a rare benign tumor that occurs primarily in infancy and early childhood. We present the rare presentation of a 12 cm sized intramuscular lipoblastoma of the thigh in a 23-year-old patient. On histology, the tumor strongly resembled an atypical lipomatous tumor due to the presence of lipoblasts and atypical stromal nuclei. The very focal lobulation and myxoid change presented the only histological hint towards a lipoblastoma. Cytogenetic and subsequent FISH evaluation of the tumor cells showed a 46,XY, t(8;15) (q12;q25) as chromosomal change with rearrangement of the PLAG1 gene. The present case indicates that lipoblastoma should enter the differential diagnosis of an 'atypical' deep seated fatty tumor in adults. The diagnostic value of cytogenetic/molecular analysis in the differential diagnosis of lipomatous tumors is underscored as well.

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Acknowledgements

This text presents research results of the Belgian program on Interuniversity Poles of Attraction initiated by the Belgian Sate, Prime Minister's Office, Science Policy Programming. Its authors assume the scientific responsibility. The authors would like to thank Belinda Carleer and Lut Mekers for their excellent technical assistance. Michel Rooseleers is acknowledged for his photographic assistance.

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Authors and Affiliations

  1. Department of Pathology; University Hospital, Catholic University of Leuven, University Hospital St. Rafaël, Minderbroedersstraat 12, 3000 , Leuven, Belgium

    Raf Sciot

  2. Department of Surgery, University Hospital, Catholic University of Leuven, Leuven, Belgium

    Ivo De Wever

  3. Center of Human Genetics, University Hospital, Catholic University of Leuven, Leuven, Belgium

    Maria Debiec-Rychter

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  1. Raf Sciot
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  2. Ivo De Wever
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  3. Maria Debiec-Rychter
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Correspondence to Raf Sciot.

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Sciot, R., De Wever, I. & Debiec-Rychter, M. Lipoblastoma in a 23-year-old male: distinction from atypical lipomatous tumor using cytogenetic and fluorescence in-situ hybridization analysis. Virchows Arch 442, 468–471 (2003). https://doi.org/10.1007/s00428-003-0799-x

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  • DOI: https://doi.org/10.1007/s00428-003-0799-x

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