Evidence for Notch-mediated lateral inhibition in organizing butterfly wing scales
- 228 Downloads
Here I present gene expression data that implicate a Notch-mediated lateral inhibition process in the spatial organization of butterfly wing scales. During early pupal development the receptor molecule Notch is expressed in a grid-like pattern in the wing epithelium, resulting in parallel rows of uniformly spaced cells with low Notch expression. Previous work has shown that these low-Notch cells express a homolog of the achaete-scute proneural transcription factors and develop into scales. All of these observations are consistent with the Drosophila model of Notch-mediated bristle determination and support the hypothesis that bristles and scales share an underlying patterning mechanism.
KeywordsHeliconius Bristle Achaete-scute Evolution Development
I thank Lisa M. Nagy and the referees for comments on the manuscript, Sean B. Carroll for the Distal-less antibody, Developmental Studies Hybridoma Bank for the Notch antibody, and W. Owen McMillan for H. erato. This work was supported by National Science Foundation grant DEB 0209441.
- Brunetti CR, Selegue JE, Monteiro A, French V, Brakefield PM, Carroll SB (2001) The generation and diversification of butterfly eyespot color patterns. Curr Biol 11:1578–1585Google Scholar
- Galant R, Skeath JB, Paddock S, Lewis DL, Carroll SB (1998) Expression pattern of a butterfly achaete-scute homolog reveals the homology of butterfly wing scales and insect sensory bristles. Curr Biol 8:807–813Google Scholar
- Mayer AG (1896) The development of the wing scales and their pigment in butterflies and moths. Bull Mus Comp Zool 29:209–236Google Scholar
- Nardi JB, Magee-Adams SM (1986) Formation of scale spacing patterns in a moth wing. 1. Epithelial feet may mediate cell rearrangement. Dev Biol 116:278–290Google Scholar
- Nijhout HF (1991) The development and evolution of butterfly wing patterns. Smithsonian Institution Press, Washington, D.C.Google Scholar
- Scoble MJ (1992) The Lepidoptera: form, function, and diversity. Oxford University Press, OxfordGoogle Scholar
- Wigglesworth V (1972) The principles of insect physiology. Methuen, New YorkGoogle Scholar
- Yoshida A, Aoki K (1989) Scale arrangement pattern in a lepidopteran wing. 1. Periodic cellular pattern in the pupal wing of Pieris rapae. Dev Growth Differ 31:601–609Google Scholar