COMT genotype is associated with plasticity in sense of body ownership: a pilot study
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The sense of body ownership constantly adapts to new environments, and awareness of a distinction between oneself and others is a fundamental ability. However, it remains unclear whether plasticity in the sense of body ownership is dependent on genetic factors. The present study investigated the influence of the catechol-O-methyltransferase (COMT) Val158Met genotype on illusory learning of a sense of body ownership and dissociation. 76 healthy Japanese participants experienced the rubber hand illusion (RHI), which is produced by sensory integration of conflicting modalities, with the intent to experimentally alter objective perceived locations and subjective ownership ratings. We found that Val/Val homozygous participants had more intense RHI experiences than Val/Met heterozygous and Met homozygous participants. Furthermore, RHI sensation was correlated with a dissociative personality trait in Val/Val homozygous participants. Our findings indicate an interaction between COMT genotype, RHI sensation, and dissociative personality traits: Val/Val genotypes were associated with RHI induction and greater vulnerability to dissociation. The findings suggest that Val/Val homozygous individuals may be more flexible regarding self-attribution/body ownership and that biological factors may contribute to reduced awareness regarding the distinction between self and others.
KeywordsBody ownership Plasticity Rubber hand illusion COMT genotype Dissociative personality trait
This work was supported by Grants-in-Aid for Scientific research (#24650142 and #15H04897) from the Japan Science and Technology (JST) Corporation, the Japan Foundation for Neuroscience and Mental Health, the Takeda Science Foundation, and the SENSHIN Medical Research Foundation. We thank Sayori Koyama, Miyuki Shimazaki, and Mikiko Kimura for assistance with the experiment.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the National Center of Neurology and Psychiatry committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- Bilder, R. M., Volavka, J., Lachman, H. M., & Grace, A. A. (2004). The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 29(11), 1943–1961.CrossRefGoogle Scholar
- Breier, A., Su, T. P., Saunders, R., Carson, R. E., Kolachana, B. S., de Bartolomeis, A., et al. (1997). Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proceedings of the National Academy of Sciences of the USA, 94(6), 2569–2574.CrossRefPubMedPubMedCentralGoogle Scholar
- Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., et al. (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. The American Journal of Human Genetics, 75(5), 807–821. CrossRefPubMedGoogle Scholar
- Colzato, L. S., Waszak, F., Nieuwenhuis, S., Posthuma, D., & Hommel, B. (2010). The flexible mind is associated with the Catechol-O-methyltransferase (COMT) Val158Met polymorphism: Evidence for a role of dopamine in the control of task switching. Neuropsychologia, 48(9), 2764–2768.CrossRefPubMedGoogle Scholar
- Krause-Utz, A., Veer, I. M., Rombouts, S. A., Bohus, M., Schmahl, C., & Elzinga, B. M. (2014). Amygdala and anterior cingulate resting-state functional connectivity in borderline personality disorder patients with a history of interpersonal trauma. Psychological Medicine, 44(13), 2889–2901.CrossRefPubMedGoogle Scholar
- Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y. M., Szumlanski, C. L., & Weinshilboum, R. M. (1996). Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6(3), 243–250.CrossRefPubMedGoogle Scholar
- Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D’Souza, C. D., Erdos, J., et al. (1996). Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proceedings of the National Academy of Sciences of the USA, 93(17), 9235–9240.CrossRefPubMedPubMedCentralGoogle Scholar
- Lotta, T., Vidgren, J., Tilgmann, C., Ulmanen, I., Melen, K., Julkunen, I., et al. (1995). Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry, 34(13), 4202–4210.CrossRefPubMedGoogle Scholar
- Vijayakumari, A. A., John, J. P., Halahalli, H. N., Paul, P., Thirunavukkarasu, P., Purushottam, M., et al. (2015). Effect of polymorphisms of three genes mediating monoamine signalling on brain morphometry in schizophrenia and healthy subjects. Clinical Psychopharmacology and Neuroscience, 13(1), 68–82.CrossRefPubMedPubMedCentralGoogle Scholar