Skip to main content
Log in

Distinct conflict resolution deficits related to different facets of Schizophrenia

  • Original Article
  • Published:
Psychological Research PRPF Aims and scope Submit manuscript

Abstract

An important issue in understanding the nature of conflict processing is whether it is a unitary or multidimensional construct. One way to examine this is to study whether people with impaired conflict processing exhibit a general pattern of deficits or whether they exhibit impairments in distinct aspects of conflict processing. One group who might exhibit conflict deficits are people with schizophrenia. Schizophrenia is a heterogeneous disorder, with one way to break down the heterogeneity of schizophrenia is to examine specific symptoms. Previous research has found that specific symptoms of schizophrenia are associated with specific deficits in conflict processing. In particular, disorganization is associated with increased response conflict, alogia is associated with increased retrieval conflict, and anhedonia is associated with increased emotional conflict. Moreover, there is evidence that different types of conflict processing are unassociated with each other. This evidence suggests that conflict processing is a multidimensional construct and that different aspects of schizophrenia are associated with impairments in processing different types of conflict.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Allen, H. A., Liddle, P. F., & Frith, C. D. (1993). Negative features, retrieval processes and verbal fluency in schizophrenia. British Journal of Psychiatry, 163, 769–775.

    Article  PubMed  Google Scholar 

  • Alpert, M., Clark, A., & Pouget, E. R. (1994). The syntactic role of pauses in the speech of schizophrenic patients with alogia. Journal of Abnormal Psychology, 103, 750–757.

    Article  PubMed  Google Scholar 

  • Alpert, M., Kotsaftis, A., & Pouget, E. R. (1997). At issue: speech fluency and schizophrenic negative signs. Schizophrenia Bulletin, 23, 171–177.

    PubMed  Google Scholar 

  • Andreasen, N. C., Arndt, S., Alliger, R., Miller, D., & Flaum, M. (1995). Symptoms of schizophrenia: methods, meanings, and mechanisms. Archives of General Psychiatry, 52, 341–351.

    PubMed  Google Scholar 

  • Badre, D., & D’Esposito, M. (2007). Functional magnetic resonance imaging evidence for a hierarchical organization of the prefrontal cortex. Journal of Cognitive Neuroscience, 19, 2082–2099.

    Article  PubMed  Google Scholar 

  • Badre, D., & Wagner, A. D. (2006). Computational and neurobiological mechanisms underlying cognitive flexibility. Proceedings of the National Academy of Sciences, 103, 7186–7191.

    Article  Google Scholar 

  • Badre, D., & Wagner, A. D. (2007). Left prefrontal cortex and the cognitive control of memory. Neuropsychologia, 45, 2883–2901.

    Article  PubMed  Google Scholar 

  • Bannister, D. (1968). The logical requirements of research into schizophrenia. British Journal of Psychiatry, 114, 181–188.

    Article  PubMed  Google Scholar 

  • Barch, D. M. (2006). What can research on schizophrenia tell us about the cognitive neuroscience of working memory. Neuroscience, 139, 73–84.

    Article  PubMed  Google Scholar 

  • Barch, D. M., & Berenbaum, H. (1994). The relationship between information processing and language production. Journal of Abnormal Psychology, 103, 241–251.

    Article  PubMed  Google Scholar 

  • Barch, D. M., Carter, C. S., Perlstein, W., Baird, J., Cohen, J. D., & Schooler, N. (1999). Increased stroop facilitation effects in schizophrenia are not due to increased automatic spreading activation. Schizophrenia Research, 39, 51–64.

    Article  PubMed  Google Scholar 

  • Becker, T. M., Cicero, D. C., & Kerns, J. G. (2007). Disorganized speech, cognitive control deficits, and emotion traits in schizophrenia. Poster presented at the Society for Research in Psychopathology, Iowa City.

  • Berenbaum, H., Kerns, J. G., Vernon, L. L., & Gomez, J. J. (2008). Cognitive correlates of schizophrenic signs and symptoms: I. Verbal communication disturbances. Psychiatry Research, 159, 147–156.

    Article  PubMed  Google Scholar 

  • Bilder, R. M., Mukherjee, S., Rieder, R. O., & Pandurangi, A. K. (1985). Symptomatic and neuropsychological components of defect states. Schizophrenia Bulletin, 11, 409–419.

    PubMed  Google Scholar 

  • Blanchard, J. J., & Cohen, A. S. (2006). The structure of negative symptoms within schizophrenia: implications for assessment. Schizophrenia Bulletin, 32, 238–245.

    Article  PubMed  Google Scholar 

  • Blanchard, J. J., & Neale, J. M. (1992). Medication effects: Conceptual and methodological issues in schizophrenia research. Clinical Psychology Review, 12, 345–361.

    Article  Google Scholar 

  • Bleuler, E. (1950). Dementia praecox or the group of schizophrenias (J. Zinkin, Trans.). New York: International Universities Press. (Original work published 1911).

  • Botvinick, M. M., Braver, T. S., Barch, D. M., Carter, C. S., & Cohen, J. D. (2001). Conflict monitoring and cognitive control. Psychological Review, 108, 624–652.

    Article  PubMed  Google Scholar 

  • Botvinick, M., & Plaut, D. C. (2004). Doing without schema hierarchies: a recurrent connectionist approach to normal and impaired routine sequential action. Psychological Review, 111, 395–429.

    Article  PubMed  Google Scholar 

  • Bowie, C. R., & Harvey, P. D. (2005). Cognition in schizophrenia: Impairments, determinants, and functional importance. Psychiatric Clinics of North America, 28, 613–633.

    Article  PubMed  Google Scholar 

  • Bunting, M. (2006). Proactive interference and item similarity in working memory. Journal of Experimental Psychology: Learning, Memory, and Cognition, 32, 183–196.

    Article  PubMed  Google Scholar 

  • Calloway, E., & Naghdi, S. (1982). An information processing model for Schizophrenia. Archives of General Psychiatry, 39, 339–347.

    Google Scholar 

  • Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998). Anterior cingulate cortex, error detection, and the online monitoring of performance. Science, 280, 747–749.

    Article  PubMed  Google Scholar 

  • Cavina-Pratesi, C., Valyear, K. F., Culham, J. C., Kohler, S., Obhi, S. S., Marzi, C. A., et al. (2006). Dissociating arbitrary stimulus-response mapping from movement planning during preparatory period: evidence from event-related functional magnetic resonance imaging. Journal of Neuroscience, 26, 2704–2713.

    Article  PubMed  Google Scholar 

  • Chapman, L. J., & Chapman, J. P. (1973). Problems in the measurement of cognitive deficits. Psychological Bulletin, 79, 380–385.

    Article  PubMed  Google Scholar 

  • Cohen, J. D., Barch, D. M., Carter, C. S., & Servan-Schreiber, D. (1999). Context-processing deficits in schizophrenia: Converging evidence from three theoretically motivated cognitive tasks. Journal of Abnormal Psychology, 108, 120–133.

    Article  PubMed  Google Scholar 

  • Cohen, J. D., Botvinick, M. M., & Carter, C. S. (2000). Anterior cingulate and prefrontal cortex: who’s in control? Nat Neurosci, 3, 421–423.

    Article  PubMed  Google Scholar 

  • Cooper, R. P., & Shallice, T. (2006). Hierarchical schemas and goals in the control of sequential behavior. Psychological Review, 113, 887–916.

    Article  PubMed  Google Scholar 

  • Costello, C. G. (1992). Research on symptoms versus research on syndromes. Arguments in favour of allocating more research time to the study of symptoms. British Journal of Psychiatry, 160, 304–308.

    Article  PubMed  Google Scholar 

  • De Houwer, J., Hermans, D., Rothermund, K., & Wentura, D. (2002). Affective priming of semantic categorization responses. Cognition and Emotion, 16, 643–666.

    Article  Google Scholar 

  • Delawalla, Z., Barch, D. M., Fisher Eastep, J. L., Thomason, E. S., Hanewinkel, M. J., Thompson, P. A., et al. (2006). Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophrenia. Schizophrenia Bulletin, 32, 525–537.

    Article  PubMed  Google Scholar 

  • Dikeos, D. G., Wickham, H., McDonald, C., Walshe, M., Sigmundsson, T., Bramon, E., et al. (2006). Distribution of symptom dimensions across Kraepelinian divisions. British Journal of Psychiatry, 189, 346–353.

    Article  PubMed  Google Scholar 

  • Docherty, N. M., Strauss, M. E., Dinzeo, T. J., & St.-Hilaire, A. (2006). The cognitive origins of specific types of schizophrenic speech disturbances. American Journal of Psychiatry, 163, 2111–2118.

    Article  PubMed  Google Scholar 

  • Fazio, R. H. (2001). On the automatic activation of associated evaluations: An overview. Cognition and Emotion, 15, 115–141.

    Article  Google Scholar 

  • Fazio, R. H., Sanbonmatsu, D. M., Powell, M. C., & Kardes, F. R. (1986). On the automatic activation of attitudes. Journal of Personality and Social Psychology, 50, 229–238.

    Article  PubMed  Google Scholar 

  • Friedman, N. P., & Miyake, A. (2004). The relations among inhibition and interference control functions: A latent-variable analysis. Journal of Experimental Psychology: General, 133, 101–135.

    Article  Google Scholar 

  • Gooding, D. C., Tallent, K. A., & Hegyi, J. V. (2001). Cognitive slippage in schizotypic individuals. Journal of Nervous and Mental Disease, 189, 750–756.

    Article  PubMed  Google Scholar 

  • Gooding, D. C., Tallent, K. A., & Matts, C. W. (2005). Clinical status of at-risk individuals 5 years later: further validation of the psychometric high-risk strategy. Journal of Abnormal Psychology, 114, 170–175.

    Article  PubMed  Google Scholar 

  • Greenwood, K. E., Landau, S., & Wykes, T. (2005). Negative symptoms and specific cognitive impairments as combined targets for improved functional outcome within cognitive remediation therapy. Schizophrenia Bulletin, 31, 910–921.

    Article  PubMed  Google Scholar 

  • Harvey, P. D., Koren, D., Reichenberg, A., & Bowie, C. R. (2006). Negative symptoms and cognitive deficits: what is the nature of their relationship? Schizophrenia Bulletin, 32, 250–258.

    Article  PubMed  Google Scholar 

  • Heydebrand, G., Weiser, M., Rabinowitz, J., Hoff, A. L., DeLisi, L. E., & Csernansky, J. G. (2004). Correlates of cognitive deficits in first episode schizophrenia. Schizophrenia Research, 68, 1–9.

    Article  PubMed  Google Scholar 

  • Johnstone, T., van Reekum, C. M., Urry, H. L., Kalin, N. H., & Davidson, R. J. (2007). Failure to regulate: counterproductive recruitment of top–down prefrontal-subcortical circuitry in major depression. Journal of Neuroscience, 27, 8877–8884.

    Article  PubMed  Google Scholar 

  • Jonides, J., Smith, E. E., Marshuetz, C., Koeppe, R. A., & Reuter-Lorenz, P. A. (1998). Inhibition in verbal working memory revealed by brain activation. Proceedings of the National Academy of Sciences, 95, 8410–8413.

    Article  Google Scholar 

  • Kerns, J. G. (2006). Schizotypy facets, cognitive control, and emotion. Journal of Abnormal Psychology, 115, 418–427.

    Article  PubMed  Google Scholar 

  • Kerns, J. G. (2007a). Verbal communication impairments and cognitive control components in people with schizophrenia. Journal of Abnormal Psychology, 116, 279–289.

    Article  PubMed  Google Scholar 

  • Kerns, J. G. (2007b). Experimental manipulation of cognitive control processes causes an increase in communication disturbances in healthy volunteers. Psychological Medicine, 37, 995–1004.

    Article  PubMed  Google Scholar 

  • Kerns, J. G., & Becker, T. M. (2008). Communication disturbances, working memory, and emotion in people with elevated disorganized schizotypy. Schizophrenia Research, 100, 172–180.

    PubMed  Google Scholar 

  • Kerns, J. G., & Berenbaum, H. (2002). Cognitive impairments associated with formal thought disorder in people with schizophrenia. Journal of Abnormal Psychology, 111, 211–224.

    Article  PubMed  Google Scholar 

  • Kerns, J. G., & Berenbaum, H. (2003). The relationship between formal thought disorder and executive functioning component processes. Journal of Abnormal Psychology, 112, 339–352.

    Article  PubMed  Google Scholar 

  • Kerns, J. G., & Berenbaum, H. (2008). Alogia and retrieval deficits on a verbal fluency task (in preparation).

  • Kerns, J. G., Cohen, J. D., MacDonald, A. W., I. I. I., Cho, R. Y., Stenger, V. A., & Carter, C. S. (2004). Anterior cingulate conflict monitoring predicts adjustments in control. Science, 303, 1023–1026.

    Article  PubMed  Google Scholar 

  • Kerns, J. G., Docherty, A. R., & Martin, E. A. (2008). Social and physical anhedonia and valence and arousal aspects of emotional experience. Journal of Abnormal Psychology (in press).

  • Kerns, J. G., Nuechterlein, K. H., Braver, T. S., & Barch, D. M. (2008b). Executive functioning component mechanisms and schizophrenia. Biological Psychiatry, 64, 26–33.

    Article  PubMed  Google Scholar 

  • Kirkpatrick, B., Fenton, W. S., Carpenter, W. T., Jr., & Marder, S. R. (2006). The NIMH-MATRICS consensus statement on negative symptoms. Schizophrenia Bulletin, 32, 214–219.

    Article  PubMed  Google Scholar 

  • Klauer, K. C., & Musch, J. (2003). Affective priming: Findings and theories. In J. Musch & K. C. Klauer (Eds.), The psychology of evaluation: Affective processes in cognition and emotion (pp. 7–49). Mahwah: Erlbaum.

    Google Scholar 

  • Klauer, K. C., Roßnagel, C., & Musch, J. (1997). List-context effects in evaluative priming. Journal of Experimental Psychology: Learning, Memory, & Cognition, 23, 246–255.

    Article  Google Scholar 

  • Koechlin, E., Ody, C., & Kouneiher, F. (2003). The architecture of cognitive control in the human prefrontal cortex. Science, 302, 1181–1185.

    Article  PubMed  Google Scholar 

  • Kwapil, T. R. (1998). Social anhedonia as a predictor of the development of schizophrenia-spectrum disorders. Journal of Abnormal Psychology, 107, 558–565.

    Article  PubMed  Google Scholar 

  • Liddle, P. F. (1987). The symptoms of chronic schizophrenia: a re-examination of the positive–negative dichotomy. British Journal of Psychiatry, 151, 145–151.

    Article  PubMed  Google Scholar 

  • Liston, C., Mattalon, S., Hare, T. A., Davidson, M. C., & Casey, B. J. (2006). Anterior cingulate and posterior parietal cortices are sensitive to dissociable forms of conflict in a task-switching paradigm. Neuron, 50, 643–653.

    Article  PubMed  Google Scholar 

  • MacDonald, A. W., I. I. I., Carter, C. S., Kerns, J. G., Ursu, S., Barch, D. M., Holmes, A. J., et al. (2005). Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. American Journal of Psychiatry, 162, 475–484.

    Article  PubMed  Google Scholar 

  • Martin, E. A., & Kerns, J. G. (2008). Social anhedonia and increased emotional but not cognitive conflict. Poster to be presented at the Society for Research in Psychopathology, Pittsburgh, PA.

  • Martin, E. A., & Kerns, J. G. (2008). Social anhedonia associated with poor emotional but not poor cognitive control (in preparation).

  • Martin, E. A., & Kerns, J. G. (2008). Facets of schizotypy and emotional control (in preparation).

  • May, C. P., Hasher, L., & Kane, M. J. (1999). The role of interference in memory span. Memory & Cognition, 27, 759–767.

    Google Scholar 

  • Melinder, M. R. D., & Barch, D. M. (2003). The influence of a working memory load manipulation on language production in schizophrenia. Schizophrenia Bulletin, 29, 473–485.

    PubMed  Google Scholar 

  • Miller, E. K., & Cohen, J. D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167–202.

    Article  PubMed  Google Scholar 

  • Mitelman, S. A., & Buchsbaum, M. S. (2007). Very poor outcome schizophrenia: clinical and neuroimaging aspects. International Review of Psychiatry, 19, 345–357.

    Article  PubMed  Google Scholar 

  • Monsell, S. (1978). Recency, immediate recognition memory, and reaction time. Cognitive Psychology, 10, 465–501.

    Article  Google Scholar 

  • Neale, J. M., & Oltmanns, T. F. (1980). Schizophrenia. New York: Wiley.

    Google Scholar 

  • Nelson, J. K., Reuter-Lorenz, P. A., Sylvester, C. Y., Jonides, J., & Smith, E. E. (2003). Dissociable neural mechanisms underlying response-based and familiarity-based conflict in working memory. Proceedings of the National Academy of Sciences, 100, 11171–11175.

    Article  Google Scholar 

  • Norman, D. A., & Shallice, T. (1986). Attention to action: willed and automatic control of behaviour. In R. J. Davidson, G. E. Schwartz, & D. Shapiro (Eds.), Consciousness and self-regulation: advances in research and theory (pp. 1–18). New York: Plenum Press.

    Google Scholar 

  • Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D., et al. (2004). For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. NeuroImage, 23, 483–499.

    Article  PubMed  Google Scholar 

  • Persons, J. B. (1986). The advantage of studying psychological phenomena rather than psychiatric diagnoses. American Psychologist, 41, 1252–1260.

    Article  PubMed  Google Scholar 

  • Reason, J. (1990). Human error. New York: Cambridge University Press.

    Google Scholar 

  • Rohrer, D., Wixted, J. T., Salmon, D. P., & Butters, N. (1995). Retrieval from semantic memory and its implications for Alzheimer’s Disease. Journal of Experimental Psychology: Learning, Memory, and Cognition, 21, 1127–1139.

    Article  PubMed  Google Scholar 

  • Rosen, V. M., & Engle, R. W. (1997). The role of working memory capacity in retrieval. Journal of Experimental Psychology: General, 126, 211–227.

    Article  Google Scholar 

  • Rougier, N. P., Noelle, D. C., Braver, T. S., Cohen, J. D., & O’Reilly, R. C. (2005). Prefrontal cortex and flexible cognitive control: rules without symbols. Proceedings of the National Academy of Sciences, 102, 7338–7343.

    Article  Google Scholar 

  • Salzinger, K. (1971). An hypothesis about schizophrenic behavior. American Journal of Psychotherapy, 25, 601–614.

    PubMed  Google Scholar 

  • Schmeichel, B. J. (2007). Attention control, memory updating, and emotion regulation temporarily reduce the capacity for executive control. Journal of Experimental Psychology: General, 136, 241–255.

    Article  Google Scholar 

  • Shakow, D. (1962). Segmental set: a theory of the formal psychological deficit in schizophrenia. Archives of General Psychiatry, 6, 1–17.

    PubMed  Google Scholar 

  • Sher, K. J., & Trull, T. J. (1996). Methodological issues in psychopathology research. Annual Review of Psychology, 47, 371–400.

    Article  PubMed  Google Scholar 

  • Stolar, N., Berenbaum, H., Banich, M. T., & Barch, D. M. (1994). Neuropsychological correlates of alogia and affective flattening in schizophrenia. Biological Psychiatry, 35, 164–172.

    Article  PubMed  Google Scholar 

  • Thompson-Schill, S. L., D’Esposito, M., Aguirre, G. K., & Farah, M. J. (1997). Role of left inferior prefrontal cortex in retrieval of semantic knowledge: a reevaluation. Proceedings of the National Academy of Sciences, 94, 14792–14797.

    Article  Google Scholar 

  • Thompson-Schill, S. L., Swick, D., Farah, M. J., D’Esposito, M., Kan, I. P., & Knight, R. T. (1998). Verb generation in patients with focal frontal lesions: a neuropsychological test of neuroimaging findings. Proceedings of the National Academy of Sciences, 95, 15855–15860.

    Article  Google Scholar 

  • Titone, D. A. (2002). Finding order in schizophrenic thought disorder. Trends in Cognitive Sciences, 6, 115.

    Article  PubMed  Google Scholar 

  • Tranel, D., Anderson, S. W., & Benton, A. (1994). Development of the concept of “executive functions” and its relationship to the frontal lobes. In F. Boller & H. Spinnler (Eds.), Handbook of neuropsychology: vol. 9, section 12. The frontal lobes (pp. 123–149). New York: Academic Press.

    Google Scholar 

  • Unsworth, N., & Engle, R. W. (2007). The nature of individual differences in working memory capacity: active maintenance in primary memory and controlled search from secondary memory. Psychological Review, 114, 104–132.

    Article  PubMed  Google Scholar 

  • Wagner, A. D., Pare-Blagoev, E. J., Clark, J., & Poldrack, R. A. (2001). Recovering meaning: left prefrontal cortex guides controlled semantic retrieval. Neuron, 31, 329–338.

    Article  PubMed  Google Scholar 

  • Wentura, D. (1999). Activation and inhibition of affective information: Evidence for negative priming in the evaluation task. Cognition and Emotion, 13, 65–91.

    Article  Google Scholar 

Download references

Acknowledgments

This research was supported by National Institute of Mental Health Grant MH072706, National Institute on Drug Abuse Grant DA022405, and a MU Research Board Grant.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John G. Kerns.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kerns, J.G. Distinct conflict resolution deficits related to different facets of Schizophrenia. Psychological Research 73, 786–793 (2009). https://doi.org/10.1007/s00426-008-0195-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00426-008-0195-x

Keywords

Navigation