, Volume 249, Issue 6, pp 1681–1694 | Cite as

Cannabimimetic plants: are they new cannabinoidergic modulators?

  • Amit Kumar
  • Marika Premoli
  • Francesca Aria
  • Sara Anna Bonini
  • Giuseppina Maccarinelli
  • Alessandra Gianoncelli
  • Maurizio Memo
  • Andrea MastinuEmail author


Main Conclusion

Phytochemicals and secondary metabolites able to interact with the endocannabinoid system (Cannabimimetics) have been recently described in a broad range of plants and fruits. These findings can open new alternative avenues to explore for the development of novel therapeutic compounds.

The cannabinoids regulate many physiological and pathological functions in both animals and plants. Cannabis sativa is the main plant that produces phytocannabinoids inside resins capable to defend the plant from the aggression of parasites and herbivores. Animals produce anandamide and 2-arachidonoyl glycerol, which thanks to binding with main receptors such as type-1 cannabinoid receptor (CB1R) and the type-2 cannabinoid receptor (CB2R) are involved in inflammation processes and several brain functions. Endogenous cannabinoids, enzymes for synthesis and degradation of cannabinoids, and CB1R and CB2R constitute the endocannabinoid system (ECS). Other plants can produce cannabinoid-like molecules such as perrottetinene extracted from Radula perrottetii, or anandamide and 2-arachidonoyl glycerol extracted from some bryophytes. Moreover, several other secondary metabolites can also interact with the ECS of animals and take the name of cannabimimetics. These phytoextracts not derived from Cannabis sativa can act as receptor agonists or antagonist, or enzyme inhibitors of ECS and can be involved in the inflammation, oxidative stress, cancer, and neuroprotection. Finally, given the evolutionary heterogeneity of the cannabimimetic plants, some authors speculated on the fascinating thesis of the evolutionary convergence between plants and animals regarding biological functions of ECS. The review aims to provide a critical and complete assessment of the botanical, chemical and therapeutic aspects of cannabimimetic plants to evaluate their spread in the world and medicinal potentiality.



This work was supported by “Research Grant from the University of Brescia EX60%MEMO” and “Petrus och Augusta Hedlunds Stiftelse; Loo och Hans Ostermans Stiftelse; Karolinska Institutet Research and Geriatrics Foundation; Gunvor och Josef Aners Stiftelse”.


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Authors and Affiliations

  1. 1.Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and SocietyCenter for Alzheimer Research, Karolinska InstitutetHuddingeSweden
  2. 2.Division of Pharmacology, Department of Molecular and Translational MedicineUniversity of BresciaBresciaItaly

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