Climate change increases the risk of herbicide-resistant weeds due to enhanced detoxification

Planta volume 244, pages1217–1227(2016)Cite this article

Abstract

Main conclusion

Global warming will increase the incidence of metabolism-based reduced herbicide efficacy on weeds and, therefore, the risk for evolution of non-target site herbicide resistance.

Climate changes affect food security both directly and indirectly. Weeds are the major biotic factor limiting crop production worldwide, and herbicides are the most cost-effective way for weed management. Processes associated with climatic changes, such as elevated temperatures, can strongly affect weed control efficiency. Responses of several grass weed populations to herbicides that inhibit acetyl-CoA carboxylase (ACCase) were examined under different temperature regimes. We characterized the mechanism of temperature-dependent sensitivity and the kinetics of pinoxaden detoxification. The products of pinoxaden detoxification were quantified. Decreased sensitivity to ACCase inhibitors was observed under elevated temperatures. Pre-treatment with the cytochrome-P450 inhibitor malathion supports a non-target site metabolism-based mechanism of herbicide resistance. The first 48 h after herbicide application were crucial for pinoxaden detoxification. The levels of the inactive glucose-conjugated pinoxaden product (M5) were found significantly higher under high- than low-temperature regime. Under high temperature, a rapid elevation in the level of the intermediate metabolite (M4) was found only in pinoxaden-resistant plants. Our results highlight the quantitative nature of non-target-site resistance. To the best of our knowledge, this is the first experimental evidence for temperature-dependent herbicide sensitivity based on metabolic detoxification. These findings suggest an increased risk for the evolution of herbicide-resistant weeds under predicted climatic conditions.

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Abbreviations

ACCase:

Acetyl-CoA carboxylase

CYT-P450:

Cytochrome P450 monooxygenase

DAT:

Days after treatment

HAT:

Hours after treatment

NTS:

Non-target site

RI:

Resistance index

TS:

Target site

TSI:

Temperature sensitivity index

ED50 :

Effective dose required to control 50% of weed population

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Acknowledgments

This study was supported by the Chief Scientist of the Israeli Ministry of Agriculture and Rural Development (Grant Nos. 837-0150-14 and 12-02-0023) and ADAMA Agricultural Solutions. The authors would like to thank M. Sibony, Z Kleinman, T. Kliper, and L. Shaar-Moshe for their assistance with the experiments. The authors would also like to thank Dr. Shiv S. Kaundun (Syngenta) for providing technical-grade pinoxaden. We are also thankful for the insightful comments provided by the anonymous reviewers.

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Affiliations

  1. The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 7610001, Rehovot, Israel

    Maor Matzrafi, Baruch Rubin & Zvi Peleg

  2. Department of Analytical Chemistry, Helmholtz-Centre for Environmental Research - UFZ, Permoserstrasse 15, 04318, Leipzig, Germany

    Bettina Seiwert & Thorsten Reemtsma

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  1. Maor Matzrafi
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  2. Bettina Seiwert
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  3. Thorsten Reemtsma
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  4. Baruch Rubin
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  5. Zvi Peleg
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Correspondence to Zvi Peleg.

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Matzrafi, M., Seiwert, B., Reemtsma, T. et al. Climate change increases the risk of herbicide-resistant weeds due to enhanced detoxification. Planta 244, 1217–1227 (2016). https://doi.org/10.1007/s00425-016-2577-4

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Keywords

  • Diclofop-methyl
  • Global warming
  • Herbicide metabolism
  • Non-target-site resistance
  • Temperature-dependent sensitivity
  • Weed management