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Unravelling triterpene glycoside synthesis in plants: phytochemistry and functional genomics join forces

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References

  • Ebizuka Y, Katsube Y, Tsutsumi T, Kushiro T, Shibuya M (2003) Functional genomics approach to the study of triterpene biosynthesis. Pure Appl Chem 75:369–374

    CAS  Google Scholar 

  • Fazio GC, Xu R, Matsuda SPT (2004) Genome mining to identify new plant triterpenoids. J Am Chem Soc 126:5678–5679

    Article  CAS  PubMed  Google Scholar 

  • Francis G, Kerem Z, Makkar HP, Becker K (2002) The biological activity of saponins in animal systems: a review. Br J Nutr 88:587–605

    Article  CAS  PubMed  Google Scholar 

  • Gierl A, Frey M (2001) Evolution of benzoxazinone biosynthesis and indole production in maize. Planta 213:493–498

    Article  CAS  PubMed  Google Scholar 

  • Hanausek M, Ganesh P, Walaszek Z, Arntzen CJ, Slaga TJ, Gutterman JU (2001) Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-it ras mutations and aneuploidy in a murine skin carcinogenesis model. Proc Natl Acad Sci USA 98:11551–11556

    Article  CAS  PubMed  Google Scholar 

  • Haralampidis K, Bryan G, Qi X, Papadopoulou K, Bakht S, Melton R, Osbourn A (2001) A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots. Proc Natl Acad Sci USA 98:13431–13436

    Article  CAS  PubMed  Google Scholar 

  • Haralampidis K, Trojanowska M, Osbourn AE (2002) Biosynthesis of triterpenoid saponins in plants. In: Scheper T (ed) Advances in biochemical engineering/biotechnology. Springer, Berlin Heidelberg New York, pp 31–49

    Google Scholar 

  • Hayashi H, Huang PY, Inoue K (2003) Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrrhiza glabra. Plant Cell Physiol 44:404–411

    Article  CAS  PubMed  Google Scholar 

  • Hostettmann K, Marston A (1995) Saponins. Cambridge Univerisity Press, Cambridge

    Google Scholar 

  • Hu XY, Neill S, Cai WM, Tang ZC (2003) Hydrogen peroxide and jasmonic acid mediate oligogalacturonic acid-induced saponin accumulation in suspension-cultured cells of Panax ginseng. Physiol Plant 118:414–421

    Article  CAS  Google Scholar 

  • Huhman DV, Sumner LW (2002). Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using HPLC coupled to an electrospray ion-trap mass spectrometer. Phytochemistry 59:347–360

    Article  CAS  PubMed  Google Scholar 

  • Hurst LD, Pal C, Lercher MJ (2004) The evolutionary dynamics of eukaryotic gene order. Nat Rev Genet 5:299–310

    Article  CAS  PubMed  Google Scholar 

  • Husselstein-Muller T, Schaller H, Benveniste P (2001) Molecular cloning and expression in yeast of 2,3-oxidosqualene- triterpenoid cyclases from Arabidopsis thaliana. Plant Mol Biol 45:75–92

    Article  CAS  PubMed  Google Scholar 

  • Iturbe-Ormaetxe I, Haralampidis K, Papadopoulou K, Osbourn AE (2003) Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus. Plant Mol Biol 51:731–743

    Article  CAS  PubMed  Google Scholar 

  • Joshi L, van Eck JM, Mayo K, di Silvestro R, Blake ME, Ganapathi T, Haridas V, Gutterman JU, Arntzen CJ (2002) Metabolomics of Plant Saponins: bioprospecting triterpene glycoside diversity with respect to mammalian cell targets. OMICS 6:235–246

    Article  CAS  PubMed  Google Scholar 

  • Jung JD, Park HW, Hahn Y, Hur CG, In DS, Chung HJ, Liu JR, Choi DW (2003) Discovery of genes for ginsenoside biosynthesis by analysis of ginseng expressed sequence tags. Plant Cell Rep 22:224–230

    Article  CAS  PubMed  Google Scholar 

  • Kawano N, Ichinose K, Ebizuka Y (2002) Molecular cloning and functional expression of cDNAs encoding oxidosqualene cyclases from Costus speciosus. Biol Pharmacol Bull 25:477–482

    Article  CAS  Google Scholar 

  • Kehr J (2003) Single cell technology. Curr Opin Plant Biol 6:617–621

    Article  CAS  PubMed  Google Scholar 

  • Marston A, Wolfender J-L, Hostettmann K (2000) Analysis and isolation of saponins from plant material. In: Oleszek W, Marston A (eds) Saponins in food, feedstuffs and medicinal plants. Kluwer, Dordrecht, pp 1–12

    Google Scholar 

  • Morrissey JP, Osbourn AE (1999) Fungal resistance to plant antibiotics as a mechanism of pathogenesis. Microbiol Mol Biol Rev 63:708–724

    CAS  PubMed  Google Scholar 

  • Oleszek W, Marston A (2000) Saponins in food, feedstuffs and medicinal plants. Kluwer, Dordrecht

    Google Scholar 

  • Osbourn AE (2003) Molecules of interest: saponins in cereals. Phytochemistry 62:1–4

    Article  CAS  PubMed  Google Scholar 

  • Papadopoulou K, Melton RE, Leggett M, Daniels MJ, Osbourn AE (1999) Compromised disease resistance in saponin-deficient plants. Proc Natl Acad Sci USA 96:12923–12928

    Article  CAS  PubMed  Google Scholar 

  • Qi X, Bakht S, Leggett M, Maxwell C, Melton R, Osbourn A (2004) A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants. Proc Natl Acad Sci USA 101:8233–8238

    Article  CAS  PubMed  Google Scholar 

  • Suzuki H, Achnine L, Xu R, Matsuda SPT, Dixon RA (2002) A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula. Plant J 32:1033–1048

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The Sainsbury Laboratory is supported by the Gatsby Charitable Foundation. B.T. is supported by the Biotechnology and Biological Sciences Research Council and H.J. by DuPont Agricultural Products.

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Correspondence to Anne Osbourn.

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Jenner, H., Townsend, B. & Osbourn, A. Unravelling triterpene glycoside synthesis in plants: phytochemistry and functional genomics join forces. Planta 220, 503–506 (2005). https://doi.org/10.1007/s00425-004-1434-z

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  • DOI: https://doi.org/10.1007/s00425-004-1434-z

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