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Rhd and C/cE/e genotyping in Slovenian population

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Abstract

The Rhesus (Rh) blood group system is, after ABO, clinically most important. Alloantibodies directed against Rh antigens are the major cause of a haemolytic disease of newborn (HDN) and of transfusion reactions. In search for novel methods for Rh genotyping we started to compare Rh genotypes identified from different tissues and Rh phenotypes. Genotypes determined from blood samples with PCR based RhD, C/c and E/e genotyping methods were compared with serologically identified phenotypes (N=32). With two exceptions the results of phenotyping and genotyping were in concordance. Two Rh serotypes from a Slovenian family that were unexpected according to the Mendelian laws were characterised genotypically. The two family members were suspected to have a chromosomal deletion on RH gene locus.

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Authors and Affiliations

  1. Blood Transfusion Centre of Slovenia, Šlajmerjeva 6, SI-1105 Ljubljana, Slovenia, , , , , , SI

    Ruth Rebeka Rupreht, Vesna Bojanič, Ljerka Glonar, Irena Bricl, Primož Rožman & Vladka Čurin Šerbec

  2. Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1067 CX Amsterdam, The Netherlands, , , , , , NL

    Brigitte Henrica Wilhelmina Faas & Petra Anna Maaskant van Wijk

Authors
  1. Ruth Rebeka Rupreht
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  2. Brigitte Henrica Wilhelmina Faas
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  3. Vesna Bojanič
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  4. Petra Anna Maaskant van Wijk
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  5. Ljerka Glonar
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  6. Irena Bricl
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  7. Primož Rožman
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  8. Vladka Čurin Šerbec
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Published: January 2000

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Rupreht, R., Faas, B., Bojanič, V. et al. Rhd and C/cE/e genotyping in Slovenian population. Pflügers Arch 439 (Suppl 1), r058–r059 (2000). https://doi.org/10.1007/s004240000091

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  • DOI: https://doi.org/10.1007/s004240000091

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