Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Vitamin C induced apoptosis in human articular chondrocytes

  • 68 Accesses

  • 15 Citations


Chondrocytes present in articular cartilage survive as a resident cell population throughout the lifespan of the individual organism. However, articular chondrocytes as other cells also undergo apoptosis and there is an ever increasing list of diverse stimuli that can induce this phenomenon in vitro. Our main interest was to investigate potential cytotoxic effects of vitamin C (L-ascorbic acid) on human articular chondrocytes. The present study suggests that vitamin C can induce apoptosis in a cell culture of chondrocytes after 18 h of cultivation. Apoptosis-inducing activity of L-ascorbic acid is dose dependent and significantly affected by the presence of serum. The increased number of vitamin C induced apoptotic cells was associated with DNA fragmentation and morphological changes of the cells.

This is a preview of subscription content, log in to check access.

Author information

Additional information

Published: January 2000

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Maličev, E., Wozniak, G., Knežević, M. et al. Vitamin C induced apoptosis in human articular chondrocytes. Pflügers Arch 440, R046–R048 (2000). https://doi.org/10.1007/s004240000001

Download citation

  • Key words vitamin C (L-ascorbic acid)
  • apoptosis
  • human articular chondrocytes