Abstract
Under normal physiological condition, the biomineralization process is limited to skeletal tissues and teeth and occurs throughout the individual’s life. Biomineralization is an actively regulated process involving the progressive mineralization of the extracellular matrix secreted by osteoblasts in bone or odontoblasts and ameloblasts in tooth. Although the detailed molecular mechanisms underlying the formation of calcium–phosphate apatite crystals are still debated, it is suggested that calcium and phosphate may need to be transported across the membrane of the mineralizing cell, suggesting a pivotal role of phosphate transporters in bone and tooth mineralization. In this context, this short review describes the current knowledge on the role of Slc34 Na+–phosphate transporters in skeletal and tooth mineralization.
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Acknowledgments
I would like to acknowledge Céline Gaucher (Université Paris Descartes) and Laure Merametdjian (Université de Nantes) for their work on phosphate transporters in the tooth and Sarah Beck-Cormier, Annabelle Bourgine, Sophie Sourice, and Nina Bon (Université de Nantes) and Greig Couasnay (Baylor College of Medicine) for their work on Slc20a1 and Slc20a2 phosphate transporters in the skeleton.
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This work was supported by grants from Institut National de la Santé et de la Recherche Médicale (INSERM), Région des Pays de la Loire (grants “Nouvelle Equipe/Nouvelle Thématique”, “Senseo,” and “Adipos”), and Institut Français sur la Recherche en Odontologie (IFRO).
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Beck, L. Expression and function of Slc34 sodium–phosphate co-transporters in skeleton and teeth. Pflugers Arch - Eur J Physiol 471, 175–184 (2019). https://doi.org/10.1007/s00424-018-2240-y
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DOI: https://doi.org/10.1007/s00424-018-2240-y