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Pflügers Archiv - European Journal of Physiology

, Volume 469, Issue 9, pp 1151–1161 | Cite as

Mu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in rats

  • Caroline Cristina-Silva
  • Victor Martins
  • Luciane H. Gargaglioni
  • Kênia C. Bícego
Neuroscience
  • 206 Downloads
Part of the following topical collections:
  1. Neuroscience

Abstract

The periaqueductal gray matter (PAG) is rich in mu and kappa opioid receptors, and this system is involved in thermoregulation, analgesia, and defensive behaviors. No study approached the involvement of the PAG opioids in body temperature (Tb) regulation during psychological stress such as restraint. Because activation of mu and kappa receptors increases and reduces Tb, respectively, we tested the hypothesis that they exert excitatory and inhibitory modulation, respectively, of the restraint-induced fever in rats. To this end, Tb, heat loss index (HLI, inference for peripheral vasoconstriction/vasodilation), and oxygen consumption (inference for thermogenesis) were monitored in unanesthetized rats, restrained or unrestrained, before and after intra-PAG microinjection of the selective mu opioid receptor antagonist (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 cyclic, CTAP; 1 and 10 μg/100 nL) or the selective kappa opioid receptor antagonist (nor-binaltorphimine dihydrochloride, nor-BNI; 1 and 4 μg/100 nL) or saline (100 nL). CTAP and nor-BNI did not change the Tb or HLI of euthermic animals. During restraint, Tb increased (1.0 ± 0.1 °C) in all groups; however, this effect was lower in those animals treated with CTAP and higher in animals treated with nor-BNI. The HLI decreased during restraint and increased after animals were released, but this response was not affected by any treatment. Restraint stress increased oxygen consumption (35.9 ± 3.9% elevation), but this response was diminished by CTAP and overstimulated by nor-BNI. Confirming our hypothesis, the results indicate that the mu and kappa opioid receptors in the PAG of rats play a pyrogenic and antipyretic role, respectively, during fever induced by restraint by affecting the thermogenic but not the heat conservation effector.

Keywords

Body temperature Heat loss index Oxygen consumption Opioid receptors Nor-BNI CTAP 

Notes

Acknowledgments

This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP undergraduate fellowship 2013/02813-9 to C.C.S.; grant 2015/04849-6 to K.C.B.) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES graduate fellowships to C.C.S. and V.M.). This study was part of the activities developed by C.C.S. for obtaining a master’s degree at the Joint Graduate Program in Physiological Sciences (PIPGCF) from UFSCar/UNESP. We thank Euclides Roberto Secato and Damares Perecim Roviero for their technical assistance.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical standards

All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Caroline Cristina-Silva
    • 1
    • 2
  • Victor Martins
    • 1
    • 2
  • Luciane H. Gargaglioni
    • 1
    • 2
  • Kênia C. Bícego
    • 1
    • 2
    • 3
  1. 1.Department of Animal Morphology and Physiology, College of Agricultural and Veterinarian SciencesSão Paulo State UniversityJaboticabalBrazil
  2. 2.National Institute of Science and Technology in Comparative Physiology (INCT-Fisiologia Comparada)JaboticabalBrazil
  3. 3.Departamento de Morfologia e Fisiologia Animal, Faculdade de Ciências Agrárias e VeterináriasUniversidade Estadual Paulista Júlio de Mesquita FilhoJaboticabalBrazil

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