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Interaction of endothelial cells with macrophages—linking molecular and metabolic signaling

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Abstract

Angiogenesis and inflammation go hand in hand in various (patho-)physiological conditions. Several studies have highlighted the interconnection between endothelial cells (ECs) and macrophages in these conditions at the level of growth factor and cytokine signaling, yet the importance of metabolism and metabolic signaling has been largely overlooked. Modulating macrophage and/or endothelial functions by interfering with metabolic pathways offers new perspectives for therapeutic strategies. In this review, we highlight the complexity of the interrelationship between the inflammatory response and angiogenesis. More in particular, the interaction between macrophages and ECs will be discussed with a special focus on how their metabolism can contribute to (patho-)physiological conditions.

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Acknowledgements

J.K. is supported by Research Foundation Flanders (FWO) Postdoctoral Fellowships, B.W. is a Heisenberg Professor and has been supported by grants from the DFG (WI 3291/1-1, 1-2, 3, and 5), and L.B. is funded by a grant of the Leopoldina German National Academy of Sciences. P.C. is supported by Federal Government Belgium grant (IUAP P7/03), long-term structural Methusalem funding by the Flemish Government, the Research Foundation Flanders (FWO), the Foundation Leducq Transatlantic Network (ARTEMIS), Foundation Against Cancer, a European Research Council (ERC) Advanced Research Grant (EU-ERC269073), and the AXA Research Fund. GE is supported by FWO (KAN2014 1.5.184.14).

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Authors and Affiliations

  1. Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, VIB, Campus Gasthuisberg O&N4, Herestraat 49-912, Leuven, 3000, Belgium

    Joanna Kalucka, Laura Bierhansl, Peter Carmeliet & Guy Eelen

  2. Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Campus Gasthuisberg O&N4, Leuven, 3000, Belgium

    Joanna Kalucka, Laura Bierhansl, Peter Carmeliet & Guy Eelen

  3. Department of Clinical Pathobiochemistry, Faculty of medicine, Institute of Clinical Chemistry and Laboratory Medicine, Dresden, Germany

    Ben Wielockx

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  1. Joanna Kalucka
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  2. Laura Bierhansl
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  3. Ben Wielockx
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  4. Peter Carmeliet
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  5. Guy Eelen
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Correspondence to Joanna Kalucka or Guy Eelen.

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Highlights:

• Endothelial cells promote the activation and differentiation of pro-angiogenic macrophages.

• Macrophages promote angiogenesis by secreting pro-angiogenic factors.

• Macrophage-released factors stimulate endothelial cell metabolism and function.

• Targeting metabolism in macrophages and endothelial cells might offer new therapeutic opportunities.

This article is part of the special issue on macrophages in tissue homeostasis in Pflügers Archiv – European Journal of Physiology

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Kalucka, J., Bierhansl, L., Wielockx, B. et al. Interaction of endothelial cells with macrophages—linking molecular and metabolic signaling. Pflugers Arch - Eur J Physiol 469, 473–483 (2017). https://doi.org/10.1007/s00424-017-1946-6

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  • DOI: https://doi.org/10.1007/s00424-017-1946-6

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