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Myofilament dysfunction as an emerging mechanism of volume overload heart failure

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Abstract

Two main hemodynamic overload mechanisms [i.e., volume and pressure overload (VO and PO, respectively] result in heart failure (HF), and these two mechanisms have divergent pathologic alterations and different pathophysiological mechanisms. Extensive evidence from animal models and human studies of PO demonstrate a clear association with alterations in Ca2+ homeostasis. By contrast, emerging evidence from animal models and patients with regurgitant valve disease and dilated cardiomyopathy point toward a more prominent role of myofilament dysfunction. With respect to VO HF, key features of excitation–contraction coupling defects, myofilament dysfunction, and extracellular matrix composition will be discussed.

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Acknowledgments

This study was supported by the National Institutes of Health R01 HL-056046 (to PAL), by funds provided by The Heart Center and Research Institute at Nationwide Children’s Hospital (to PAL), and by a fellowship from Genentech through the American College of Veterinary Pathologists and Society of Toxicologic Pathology Coalition for Veterinary Pathology Fellows (to KL).

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Authors and Affiliations

  1. Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children’s Hospital, Columbus, OH, USA

    Kristin Wilson & Pamela A. Lucchesi

  2. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA

    Kristin Wilson

  3. Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA

    Pamela A. Lucchesi

  4. Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children’s Hospital, 575 Children’s Crossroads, WB-4157, Columbus, OH, 43215, USA

    Pamela A. Lucchesi

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  1. Kristin Wilson
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Correspondence to Pamela A. Lucchesi.

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Wilson, K., Lucchesi, P.A. Myofilament dysfunction as an emerging mechanism of volume overload heart failure. Pflugers Arch - Eur J Physiol 466, 1065–1077 (2014). https://doi.org/10.1007/s00424-014-1455-9

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  • DOI: https://doi.org/10.1007/s00424-014-1455-9

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