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Pflügers Archiv - European Journal of Physiology

, Volume 465, Issue 12, pp 1661–1670 | Cite as

Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease

  • Amy McCurley
  • Adam McGraw
  • Dafina Pruthi
  • Iris Z. JaffeEmail author
Invited Review

Abstract

The mineralocorticoid receptor (MR), a member of the steroid receptor family, regulates blood pressure by mediating the effects of the hormone aldosterone on renal sodium handling. In recent years, it has become clear that MR is expressed in vascular smooth muscle cells (SMCs), and interest has grown in understanding the direct role of SMC MR in regulating vascular function. This interest stems from multiple clinical studies where MR inhibitor treatment reduced the incidence of cardiovascular events and mortality. This review summarizes the most recent advances in our understanding of SMC MR in regulating normal vascular function and in promoting vascular disease. Many new studies suggest a role for SMC MR activation in stimulating vascular contraction and contributing to vessel inflammation, fibrosis, and remodeling. These detrimental vascular effects of MR activation appear to be independent of changes in blood pressure and are synergistic with the presence of endothelial dysfunction or damage. Thus, in humans with underlying cardiovascular disease or cardiovascular risk factors, SMC MR activation may promote hypertension, atherosclerosis, and vascular aging. Further exploration of the molecular mechanisms for the effects of SMC MR activation has the potential to identify novel therapeutic targets to prevent or treat common cardiovascular disorders.

Keywords

Aldosterone Mineralocorticoid receptor (MR) Atherosclerosis Hypertension Inflammation Vascular remodeling Vascular aging 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Amy McCurley
    • 1
  • Adam McGraw
    • 1
  • Dafina Pruthi
    • 1
  • Iris Z. Jaffe
    • 1
    Email author
  1. 1.Molecular Cardiology Research InstituteTufts Medical CenterBostonUSA

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