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Compartmentalization of cyclic nucleotide signaling: a question of when, where, and why?

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Abstract

Preciseness of cellular behavior depends upon how an extracellular cue mobilizes a correct orchestra of cellular messengers and effector proteins spatially and temporally. This concept, termed compartmentalization of cellular signaling, is now known to form the molecular basis of many aspects of cellular behavior in health and disease. The cyclic nucleotides cyclic adenosine monophosphate and cyclic guanosine monophosphate are ubiquitous cellular messengers that can be compartmentalized in three ways: first, by their physical containment; second, by formation of multiple protein signaling complexes; and third, by their selective depletion. Compartmentalized cyclic nucleotide signaling is a very prevalent response among all cell types. In order to understand how it becomes relevant to cellular behavior, it is important to know how it is executed in cells to regulate physiological responses and, also, how its execution or dysregulation can lead to a pathophysiological condition, which forms the scope of the presented review.

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Acknowledgments

We thank Ms. Jin Emerson-Cobb for editing the manuscript. This work was supported by grants DK080834 and DK093045 from the US National Institutes of Health (NIH) and US Cystic Fibrosis Foundation NAREN12PO.

Conflict of interest

Authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

    Kavisha Arora, Chandrima Sinha, Weiqiang Zhang, Aixia Ren, Chang Suk Moon, Sunitha Yarlagadda & Anjaparavanda P. Naren

  2. University of Tennessee Cystic Fibrosis Care and Research Center at Le Bonheur Children’s Hospital, Memphis, TN, 38103, USA

    Weiqiang Zhang

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  1. Kavisha Arora
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  2. Chandrima Sinha
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  3. Weiqiang Zhang
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  4. Aixia Ren
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  6. Sunitha Yarlagadda
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  7. Anjaparavanda P. Naren
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Correspondence to Anjaparavanda P. Naren.

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Arora, K., Sinha, C., Zhang, W. et al. Compartmentalization of cyclic nucleotide signaling: a question of when, where, and why?. Pflugers Arch - Eur J Physiol 465, 1397–1407 (2013). https://doi.org/10.1007/s00424-013-1280-6

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  • DOI: https://doi.org/10.1007/s00424-013-1280-6

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