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Physiology of potassium channels in the inner membrane of mitochondria

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Abstract

The inner membrane of the ATP-producing organelles of endosymbiotic origin, mitochondria, has long been considered to be poorly permeable to cations and anions, since the strict control of inner mitochondrial membrane permeability is crucial for efficient ATP synthesis. Over the past 30 years, however, it has become clear that various ion channels—along with antiporters and uniporters—are present in the mitochondrial inner membrane, although at rather low abundance. These channels are important for energy supply, and some are a decisive factor in determining whether a cell lives or dies. Their electrophysiological and pharmacological characterisations have contributed importantly to the ongoing elucidation of their pathophysiological roles. This review gives an overview of recent advances in our understanding of the functions of the mitochondrial potassium channels identified so far. Open issues concerning the possible molecular entities giving rise to the observed activities and channel protein targeting to mitochondria are also discussed.

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Acknowledgements

The authors are grateful to all co-authors of the research performed by their groups and reported in this review, for their important contributions. The work carried out in the authors’ laboratories was supported in part by Italian Association for Cancer Research grants (to I.S. n. 5118 and to M.Z.), an European Molecular Biology Organization Young Investigator Program and a Progetti di Rilevante Interesse Nazionale grant (to I.S.), by DFG-grant Gu 335/13-3, the International Association for Cancer Research (to E.G.) and by a Fondazione CARIPARO grant (to M.Z.).

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  1. Department of Biology, University of Padova, Padova, Italy

    Ildikò Szabò & Luigi Leanza

  2. Department of Molecular Biology, University of Duisburg-Essen, Duisburg-Essen, Germany

    Erich Gulbins

  3. Department of Biomedical Sciences, University of Padova, Padova, Italy

    Mario Zoratti

  4. CNR Institute of Neuroscience, Padova, Italy

    Mario Zoratti

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  1. Ildikò Szabò
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Correspondence to Ildikò Szabò.

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Szabò, I., Leanza, L., Gulbins, E. et al. Physiology of potassium channels in the inner membrane of mitochondria. Pflugers Arch - Eur J Physiol 463, 231–246 (2012). https://doi.org/10.1007/s00424-011-1058-7

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