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Functional neuroimaging of the reciprocal influences between sleep and wakefulness

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Abstract

The activity patterns adopted by brain neuronal populations differ dramatically between wakefulness and sleep. However, these vigilance states are not independent and they reciprocally interact. Here, we provide evidence that in humans, regional brain activity during wakefulness is influenced by sleep regulation, namely by the interaction between sleep homeostasis and circadian signals. We also show that, by contrast, regional brain activity during sleep is influenced by the experience acquired during the preceding waking period. These data reveal the dynamic interactions by which the succession of vigilance states support normal brain function and human cognition.

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Acknowledgments

Personal research reported in this review was supported by the Belgian Fonds National de la Recherche Scientifique (F.N.R.S), Fondation Médicale Reine Elisabeth (FMRE), Research Fund of the University of Liège (ULg), and “Interuniversity Attraction Poles Programme–Belgian State–Belgian Science Policy.” VM is supported by the ULg. ZJ, LaM, CK, AF, AS, GV, and PM are supported by the F.N.R.S.

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Authors and Affiliations

  1. Cyclotron Research Centre (B30), University of Liège, 6, Allée du 8 Août, 4000, Liège, Belgium

    Zayd Jedidi, Estelle Rikir, Vincenzo Muto, Laura Mascetti, Caroline Kussé, Ariane Foret, Anahita Shaffii-Le Bourdiec, Gilles Vandewalle & Pierre Maquet

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  1. Zayd Jedidi
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  2. Estelle Rikir
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Correspondence to Pierre Maquet.

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This article is published as part of the Special Issue on Sleep.

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Jedidi, Z., Rikir, E., Muto, V. et al. Functional neuroimaging of the reciprocal influences between sleep and wakefulness. Pflugers Arch - Eur J Physiol 463, 103–109 (2012). https://doi.org/10.1007/s00424-011-1016-4

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