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Toward the roles of store-operated Ca2+ entry in skeletal muscle

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Abstract

Store-operated Ca2+ entry (SOCE) has been found to be a rapidly activated robust mechanism in skeletal muscle fibres. It is conducted across the junctional membranes by stromal interacting molecule 1 (STIM1) and Orai1, which are housed in the sarcoplasmic reticulum (SR) and tubular (t-) system, respectively. These molecules that conduct SOCE appear evenly distributed throughout the SR and t-system of skeletal muscle, allowing for rapid and local control in response to depletions of Ca2+ from SR. The significant depletion of SR Ca2+ required to reach the activation threshold for SOCE could only be achieved during prolonged bouts of excitation–contraction coupling (EC coupling) in a healthy skeletal muscle fibre, meaning that this mechanism is not responsible for refilling the SR with Ca2+ during periods of fibre quiescence. While Ca2+ in SR remains below the activation threshold for SOCE, a low-amplitude persistent Ca2+ influx is provided to the junctional cleft. This article reviews the properties of SOCE in skeletal muscle and the proposed molecular mechanism, assesses its potential physiological roles during EC coupling, namely refilling the SR with Ca2+ and simple balancing of Ca2+ within the cell, and also proposes the possibility of SOCE as a potential regulator of t-system and SR membrane protein function.

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Abbreviations

SR:

Sarcoplasmic reticulum

SOCE:

Store-operated Ca2+ entry

t-system:

Tubular system

EC coupling:

Excitation–contraction coupling

ER:

Endoplasmic reticulum

CSQ:

Calsequestrin

DHPR:

Dihydropyridine receptor

RyR:

Ryanodine receptor

STIM:

Stromal interacting molecule

TnC:

Troponin C

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Acknowledgements

We thank D. George Stephenson (La Trobe University, Melbourne) for the helpful comments on the manuscript. This work was supported by the Australian Research Council Discovery Project and the National Health and Medical Research Council (NHMRC; Australia) Project Grant to BS Launikonis. RM Murphy was a Peter Doherty Fellow of the NHMRC.

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Authors and Affiliations

  1. School of Biomedical Sciences, University of Queensland, Brisbane, QLD, 4072, Australia

    Bradley S. Launikonis & Joshua N. Edwards

  2. Department of Zoology, La Trobe University, Melbourne, VIC, 3086, Australia

    Robyn M. Murphy

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  1. Bradley S. Launikonis
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  3. Joshua N. Edwards
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Correspondence to Bradley S. Launikonis.

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Launikonis, B.S., Murphy, R.M. & Edwards, J.N. Toward the roles of store-operated Ca2+ entry in skeletal muscle. Pflugers Arch - Eur J Physiol 460, 813–823 (2010). https://doi.org/10.1007/s00424-010-0856-7

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