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Functional roles of TRPC channels in the developing brain

  • Ion Channels, Receptors and Transporters
  • Published:
Pflügers Archiv - European Journal of Physiology Aims and scope Submit manuscript

Abstract

Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels formed by homomeric or heteromeric complexes of TRPC proteins that contain six transmembrane domains. These channels can be activated through a phospholipase-C-dependent mechanism, making them sensors for environmental cues. Their expression begins early in embryonic days and remains in adulthood. These channels have important roles in the processes of neuronal development, including neural stem cell proliferation, cerebellar granule cell survival, axon path finding, neuronal morphogenesis, and synaptogenesis. In this review, we will discuss functional implications of TRPC channels during brain development.

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Acknowledgment

This work was supported by grants from the 973 Program (2006CB806600) and projects 30711120566 and 30621062 from the National Natural Science Foundation of China.

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  1. Laboratory of Neural Signal Transduction, Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Shanghai, 200031, China

    Yizheng Wang

  2. Graduate School, Chinese Academy of Science, 320 Yueyang Road, Shanghai, 200031, China

    Yilin Tai, Shengjie Feng & Wanlu Du

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  1. Yilin Tai
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Correspondence to Yizheng Wang.

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Tai, Y., Feng, S., Du, W. et al. Functional roles of TRPC channels in the developing brain. Pflugers Arch - Eur J Physiol 458, 283–289 (2009). https://doi.org/10.1007/s00424-008-0618-y

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