Fig. 8
From: Presynaptically expressed long-term depression at cerebellar parallel fiber synapses
Intracellularly recorded 4 Hz PF–PN LTD also required the activation of NMDA but not of mGlu1 receptors. a 1 Representative examples of EPSCs elicited by paired-pulse stimulation in control conditions and in the presence of 50 μM D-APV before (solid lines) and after (dashed lines) 4 Hz stimulation. Each trace is an average of three pairs of EPSCs to two PF stimuli delivered 50 ms apart. a 2 Summary of the experiments in which the 4 Hz stimulation induction protocol was delivered under control conditions (filled circles, n = 7) and in the presence of 50 μM D-APV (open circles, n = 9). a 3 Time course of mean PPR (second EPSC/first EPSC, normalized to baseline levels). b 1–3 Same as a 1–3 except that control conditions (filled circles, n = 7) were compared with recordings in the presence of 1 μM JNJ16259685 (open cirles, n = 9). Data points are presented as the mean±SEM