Fig. 5
From: Presynaptically expressed long-term depression at cerebellar parallel fiber synapses
PF presynaptic LTD does not require mGlu4 or GABAB receptor activation or NO. LTD of the PF Ca2+ transients was not prevented by the mGlu4 receptor antagonist CPPG (a) or by the GABAB receptor antagonist CGP (b). c Blockade of nitric oxide synthase (L-NNA; 10 μM and 100 μM) did not prevent induction of LTD. Note enhanced amount of LTD in the presence of 100 μM L-NNA. Controls in a, b, and c are from the same interlaced experiments. d Mean depression of PF calcium transients in the presence of antagonists. All experiments were conducted in the presence of 10 μM H-89. Data points are presented as the mean±SEM