Fig. 1
From: Presynaptically expressed long-term depression at cerebellar parallel fiber synapses
4 Hz parallel fiber stimulation induced LTD at parallel fiber–Purkinje cell synapses: increase in PPR and requirement for activation of CB1 receptors. a Representative examples of EPSCs elicited by paired-pulse stimulation in the presence of 10 μM H-89, 10 μM L-NNA (control), and with additional 5 μM AM251 before (dashed lines) and after (solid lines) 4 Hz stimulation. Each trace is an average of three pairs of EPSCs to two PF stimuli delivered 50 ms apart. Time course of mean EPSC amplitude (b) and PPR (c) of experiments in which the 4-Hz stimulation induction protocol was delivered under control conditions (filled circles, n = 7) and in the presence of AM251 (open circles, n = 6). Error bars indicate ±SEM