Skip to main content

TRP channels and mechanosensory transduction: insights into the arterial myogenic response

Pflügers Archiv - European Journal of Physiology volume 456, pages 529–540 (2008)Cite this article

Abstract

Mechano-gated ion channels are implicated in a variety of key physiological functions ranging from touch sensitivity to arterial pressure regulation. Seminal work in prokaryotes and invertebrates provided strong evidence for the role of specific ion channels in volume regulation, touch sensitivity, or hearing, specifically the mechanosensitive channel subunits of large and small conductances (MscL and MscS), the mechanosensory channel subunits (MEC) and the transient receptor potential channel subunits (TRP). In mammals, recent studies further indicate that members of the TRP channel family may also be considered as possible candidate mechanosensors responding to either tension, flow, or changes in cell volume. However, contradictory results have challenged whether these TRP channels, including TRPC1 and TRPC6, are directly activated by mechanical stimulation. In the present review, we will focus on the mechanosensory function of TRP channels, discuss whether a direct or indirect mechanism is at play, and focus on the proposed role for these channels in the arterial myogenic response to changes in intraluminal pressure.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. Anyatonwu GI, Estrada M, Tian X, Somlo S, Ehrlich BE (2007) Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci USA 104:6454–6459

    PubMed  Article  CAS  Google Scholar 

  2. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D (2006) TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124:1269–1282

    PubMed  Article  CAS  Google Scholar 

  3. Beech DJ (2005) Emerging functions of 10 types of TRP cationic channel in vascular smooth muscle. Clin Exp Pharmacol Physiol 32:597–603

    PubMed  Article  CAS  Google Scholar 

  4. Beech DJ (2005) TRPC1: store-operated channel and more. Pflugers Arch 451:53–60

    PubMed  Article  CAS  Google Scholar 

  5. Bichet D, Peters D, Patel A, Delmas P, Honoré E (2006) The cardiovascular polycystins: insights from autosomal dominant polycystic kidney disease and transgenic animal models. Trends Cardiovasc Med 16:292–298

    PubMed  Article  CAS  Google Scholar 

  6. Bode F, Sachs F, Franz MR (2001) Tarantula peptide inhibits atrial fibrillation. Nature 409:35–36

    PubMed  Article  CAS  Google Scholar 

  7. Bourque CW, Oliet SH, Richard D (1994) Osmoreceptors, osmoreception, and osmoregulation. Front Neuroendocrinol 15:231–274

    PubMed  Article  CAS  Google Scholar 

  8. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306–313

    PubMed  Article  CAS  Google Scholar 

  9. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398:436–441

    PubMed  Article  CAS  Google Scholar 

  10. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824

    PubMed  Article  CAS  Google Scholar 

  11. Christensen AP, Corey DP (2007) TRP channels in mechanosensation: direct or indirect activation? Nat Rev Neurosci 8:510–521

    PubMed  Article  CAS  Google Scholar 

  12. Ciura S, Bourque CW (2006) Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. J Neurosci 26:9069–9075

    PubMed  Article  CAS  Google Scholar 

  13. Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517–524

    PubMed  Article  CAS  Google Scholar 

  14. Colbert HA, Smith TL, Bargmann CI (1997) OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci 17:8259–8269

    PubMed  CAS  Google Scholar 

  15. Corey DP (2006) What is the hair cell transduction channel? J Physiol 576:23–28

    PubMed  Article  CAS  Google Scholar 

  16. Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Geleoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DS (2004) TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432:723–730

    PubMed  Article  CAS  Google Scholar 

  17. Cuajungco MP, Grimm C, Oshima K, D’Hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S (2006) PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem 281:18753–18762

    PubMed  Article  CAS  Google Scholar 

  18. Davis MJ, Hill MA (1999) Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79:387–423

    PubMed  CAS  Google Scholar 

  19. Delmas P (2005) Polycystins: polymodal receptor/ion-channel cellular sensors. Pflugers Arch 451:264–276

    PubMed  Article  CAS  Google Scholar 

  20. Denis V, Cyert MS (2002) Internal Ca(2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue. J Cell Biol 156:29–34

    PubMed  Article  CAS  Google Scholar 

  21. Dietrich A, Kalwa H, Storch U, Mederos YSM, Salanova B, Pinkenburg O, Dubrovska G, Essin K, Gollasch M, Birnbaumer L, Gudermann T (2007) Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch 455:465–477

    PubMed  Article  CAS  Google Scholar 

  22. Dietrich A, Mederos YSM, Gollasch M, Gross V, Storch U, Dubrovska G, Obst M, Yildirim E, Salanova B, Kalwa H, Essin K, Pinkenburg O, Luft FC, Gudermann T, Birnbaumer L (2005) Increased vascular smooth muscle contractility in TRPC6 −/− mice. Mol Cell Biol 25:6980–6989

    PubMed  Article  CAS  Google Scholar 

  23. Earley S, Straub SV, Brayden JE (2007) Protein kinase C regulates vascular myogenic tone through activation of TRPM4. Am J Physiol Heart Circ Physiol 292:H2613–2622

    PubMed  Article  CAS  Google Scholar 

  24. Earley S, Waldron BJ, Brayden JE (2004) Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Circ Res 95:922–929

    PubMed  Article  CAS  Google Scholar 

  25. Gao X, Wu L, O'Neil RG (2003) Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. J Biol Chem 278:27129–27137

    PubMed  Article  CAS  Google Scholar 

  26. Giamarchi A, Padilla F, Coste B, Raoux M, Crest M, Honoré E, Delmas P (2006) The versatile nature of the calcium-permeable cation channel TRPP2. EMBO Rep 7:787–793

    PubMed  Article  CAS  Google Scholar 

  27. Giamarchi A, Padilla F, Crest M, Honoré E, Delmas P (2006) TRPP2: calcium permeable cation channel and more. Cell Mol Biol 52:105–114

    PubMed  CAS  Google Scholar 

  28. Gillespie PG, Walker RG (2001) Molecular basis of mechanosensory transduction. Nature 413:194–202

    PubMed  Article  CAS  Google Scholar 

  29. Goodman MB, Schwarz EM (2003) Transducing touch in Caenorhabditis elegans. Annu Rev Physiol 65:429–452

    PubMed  Article  CAS  Google Scholar 

  30. Gottlieb P, Folgering J, Maroto R, Raso A, Wood TG, Kurosky A, Bowman C, Bichet D, Patel A, Sachs F, Martinac B, Hamill OP, Honore E (2007) Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch (in press) DOI 10.1007/s00424-007-0359-3

  31. Grimm C, Kraft R, Sauerbruch S, Schultz G, Harteneck C (2003) Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278:21493–21501

    PubMed  Article  CAS  Google Scholar 

  32. Guharay F, Sachs F (1984) Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. J Physiol 352:685–701

    PubMed  CAS  Google Scholar 

  33. Hamill OP (2006) Twenty odd years of stretch-sensitive channels. Pflugers Arch 453:333–351

    PubMed  Article  CAS  Google Scholar 

  34. Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG (2000) Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 408:990–994

    PubMed  Article  CAS  Google Scholar 

  35. Hartmannsgruber V, Heyken WT, Kacik M, Kaistha A, Grgic I, Harteneck C, Liedtke W, Hoyer J, Kohler R (2007) Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS ONE 2:e827

    PubMed  Article  CAS  Google Scholar 

  36. He Y, Yao G, Savoia C, Touyz RM (2005) Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II. Circ Res 96:207–215

    PubMed  Article  CAS  Google Scholar 

  37. Hill K, Schaefer M (2007) TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine. J Biol Chem 282:7145–7153

    PubMed  Article  CAS  Google Scholar 

  38. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259–263

    PubMed  Article  CAS  Google Scholar 

  39. Hofmann T, Schaefer M, Schultz G, Gudermann T (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 99:7461–7466

    PubMed  Article  CAS  Google Scholar 

  40. Honoré E (2007) The neuronal background K2P channels: focus on TREK-1. Nature Rev Neurosci 8:251–261

    Article  CAS  Google Scholar 

  41. Honoré E, Patel AJ, Chemin J, Suchyna T, Sachs F (2006) Desensitization of mechano-gated K2P channels. Proc Natl Acad Sci USA 103:6859–6864

    PubMed  Article  CAS  Google Scholar 

  42. Huang AL, Chen X, Hoon MA, Chandrashekar J, Guo W, Trankner D, Ryba NJ, Zuker CS (2006) The cells and logic for mammalian sour taste detection. Nature 442:934–938

    PubMed  Article  CAS  Google Scholar 

  43. Huber TB, Schermer B, Muller RU, Hohne M, Bartram M, Calixto A, Hagmann H, Reinhardt C, Koos F, Kunzelmann K, Shirokova E, Krautwurst D, Harteneck C, Simons M, Pavenstadt H, Kerjaschki D, Thiele C, Walz G, Chalfie M, Benzing T (2006) Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci USA 103:17079–17086

    PubMed  Article  CAS  Google Scholar 

  44. Hughes J, Ward CJ, Peral B, Aspinwall R, Clark K, San Millan JL, Gamble V, Harris PC (1995) The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. Nat Genet 10:151–160

    PubMed  Article  CAS  Google Scholar 

  45. Inoue R, Jensen LJ, Shi J, Morita H, Nishida M, Honda A, Ito Y (2006) Transient receptor potential channels in cardiovascular function and disease. Circ Res 99:119–131

    PubMed  Article  CAS  Google Scholar 

  46. Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y (2001) The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res 88:325–332

    PubMed  CAS  Google Scholar 

  47. Ishimaru Y, Inada H, Kubota M, Zhuang H, Tominaga M, Matsunami H (2006) Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci USA 103:12569–12574

    PubMed  Article  CAS  Google Scholar 

  48. Kim J, Chung YD, Park DY, Choi S, Shin DW, Soh H, Lee HW, Son W, Yim J, Park CS, Kernan MJ, Kim C (2003) A TRPV family ion channel required for hearing in Drosophila. Nature 424:81–84

    PubMed  Article  CAS  Google Scholar 

  49. Kindt KS, Viswanath V, Macpherson L, Quast K, Hu H, Patapoutian A, Schafer WR (2007) Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci 10:568–577

    PubMed  Article  CAS  Google Scholar 

  50. Kung C (2005) A possible unifying principle for mechanosensation. Nature 436:647–654

    PubMed  Article  CAS  Google Scholar 

  51. Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP (2006) TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50:277–289

    PubMed  Article  CAS  Google Scholar 

  52. Li Q, Montalbetti N, Wu Y, Ramos AJ, Raychowdhury MK, Chen XZ, Cantiello HF (2006) Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells. J Biol Chem 281:37566–37575

    PubMed  Article  CAS  Google Scholar 

  53. Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103:525–535

    PubMed  Article  CAS  Google Scholar 

  54. Liedtke W, Tobin DM, Bargmann CI, Friedman JM (2003) Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci USA 100(Suppl 2):14531–14536

    PubMed  Article  CAS  Google Scholar 

  55. Liu X, Bandyopadhyay B, Nakamoto T, Singh B, Liedtke W, Melvin JE, Ambudkar I (2006) A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem 281:15485–15495

    PubMed  Article  CAS  Google Scholar 

  56. Lukacs V, Thyagarajan B, Varnai P, Balla A, Balla T, Rohacs T (2007) Dual regulation of TRPV1 by phosphoinositides. J Neurosci 27:7070–7080

    PubMed  Article  CAS  Google Scholar 

  57. Maroto R, Raso A, Wood TG, Kurosky A, Martinac B, Hamill OP (2005) TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol 7:179–185

    PubMed  Article  CAS  Google Scholar 

  58. Morita H, Honda A, Inoue R, Ito Y, Abe K, Nelson MT, Brayden JE (2007) Membrane stretch-induced activation of a TRPM4-like nonselective cation channel in cerebral artery myocytes. J Pharmacol Sci 103:417–426

    PubMed  Article  CAS  Google Scholar 

  59. Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M, Imaizumi Y (2003) TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 93:829–838

    PubMed  Article  CAS  Google Scholar 

  60. Nadler MJ, Hermosura MC, Inabe K, Perraud AL, Zhu Q, Stokes AJ, Kurosaki T, Kinet JP, Penner R, Scharenberg AM, Fleig A (2001) LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature 411:590–595

    PubMed  Article  CAS  Google Scholar 

  61. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33:129–137

    PubMed  Article  CAS  Google Scholar 

  62. Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165–217

    PubMed  Article  CAS  Google Scholar 

  63. Nilius B, Prenen J, Droogmans G, Voets T, Vennekens R, Freichel M, Wissenbach U, Flockerzi V (2003) Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem 278:30813–30820

    PubMed  Article  CAS  Google Scholar 

  64. Nilius B, Prenen J, Wissenbach U, Bodding M, Droogmans G (2001) Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells. Pflugers Arch 443:227–233

    PubMed  Article  CAS  Google Scholar 

  65. Nilius B, Vennekens R (2006) From cardiac cation channels to the molecular dissection of the transient receptor potential channel TRPM4. Pflugers Arch 453:313–321

    PubMed  Article  CAS  Google Scholar 

  66. Nilius B, Vriens J, Prenen J, Droogmans G, Voets T (2004) TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol 286:C195–205

    PubMed  Article  CAS  Google Scholar 

  67. Numata T, Shimizu T, Okada Y (2007) Direct mechano-stress sensitivity of TRPM7 channel. Cell Physiol Biochem 19:1–8

    PubMed  Article  CAS  Google Scholar 

  68. Numata T, Shimizu T, Okada Y (2007) TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells. Am J Physiol Cell Physiol 292:C460–467

    PubMed  Article  CAS  Google Scholar 

  69. O'Neil RG, Heller S (2005) The mechanosensitive nature of TRPV channels. Pflugers Arch 451:193–203

    PubMed  Article  CAS  Google Scholar 

  70. Oancea E, Wolfe JT, Clapham DE (2006) Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res 98:245–253

    PubMed  Article  CAS  Google Scholar 

  71. Oliet SH, Bourque CW (1993) Mechanosensitive channels transduce osmosensitivity in supraoptic neurons. Nature 364:341–343

    PubMed  Article  CAS  Google Scholar 

  72. Owsianik G, D'Hoedt D, Voets T, Nilius B (2006) Structure–function relationship of the TRP channel superfamily. Rev Physiol Biochem Pharmacol 156:61–90

    PubMed  Article  CAS  Google Scholar 

  73. Owsianik G, Talavera K, Voets T, Nilius B (2006) Permeation and selectivity of TRP channels. Annu Rev Physiol 68:685–717

    PubMed  Article  CAS  Google Scholar 

  74. Palmer CP, Zhou XL, Lin J, Loukin SH, Kung C, Saimi Y (2001) A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca(2+)-permeable channel in the yeast vacuolar membrane. Proc Natl Acad Sci USA 98:7801–7805

    PubMed  Article  CAS  Google Scholar 

  75. Patel AJ, Honoré E, Maingret F, Lesage F, Fink M, Duprat F, Lazdunski M (1998) A mammalian two pore domain mechano-gated S-like K+ channel. EMBO J 17:4283–4290

    PubMed  Article  CAS  Google Scholar 

  76. Patel AJ, Lazdunski M, Honoré E (2001) Lipid and mechano-gated 2P domain K+ channels. Curr Opin Cell Biol 13:422–428

    PubMed  Article  CAS  Google Scholar 

  77. Pedersen SA, Nilius B (2007) Transient receptor potential channels in mechanosensing and cell volume regulation. Methods Enzymol 428:183–207

    PubMed  Article  CAS  Google Scholar 

  78. Pedersen SF, Owsianik G, Nilius B (2005) TRP channels: an overview. Cell Calcium 38:233–252

    PubMed  Article  CAS  Google Scholar 

  79. Praetorius HA, Spring KR (2003) The renal cell primary cilium functions as a flow sensor. Curr Opin Nephrol Hypertens 12:517–520

    PubMed  Article  Google Scholar 

  80. Runnels LW, Yue L, Clapham DE (2001) TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291:1043–1047

    PubMed  Article  CAS  Google Scholar 

  81. Runnels LW, Yue L, Clapham DE (2002) The TRPM7 channel is inactivated by PIP2 hydrolysis. Nat Cell Biol 4:329–336

    PubMed  CAS  Google Scholar 

  82. Sachs F (1997) Mechanical transduction by ion channels: how forces reach the channel. Soc Gen Physiol Ser 52:209–218

    PubMed  CAS  Google Scholar 

  83. Sharif Naeini R, Witty MF, Seguela P, Bourque CW (2006) An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci 9:93–98

    PubMed  Article  CAS  Google Scholar 

  84. Sidi S, Friedrich RW, Nicolson T (2003) NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science 301:96–99

    PubMed  Article  CAS  Google Scholar 

  85. Spassova MA, Hewavitharana T, Xu W, Soboloff J, Gill DL (2006) A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci USA 103:16586–16591

    PubMed  Article  CAS  Google Scholar 

  86. Stein AT, Ufret-Vincenty CA, Hua L, Santana LF, Gordon SE (2006) Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J Gen Physiol 128:509–522

    PubMed  Article  CAS  Google Scholar 

  87. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2:695–702

    PubMed  Article  CAS  Google Scholar 

  88. Suchyna TM, Tape SE, Koeppe RE 2nd, Andersen OS, Sachs F, Gottlieb PA (2004) Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature 430:235–240

    PubMed  Article  CAS  Google Scholar 

  89. Sukharev S, Corey DP (2004) Mechanosensitive channels: multiplicity of families and gating paradigms. Science’s STKE 219:1–24

    Google Scholar 

  90. Takenaka T, Suzuki H, Okada H, Hayashi K, Kanno Y, Saruta T (1998) Mechanosensitive cation channels mediate afferent arteriolar myogenic constriction in the isolated rat kidney. J Physiol 511(Pt 1):245–253

    PubMed  Article  CAS  Google Scholar 

  91. Takenaka T, Suzuki H, Okada H, Hayashi K, Ozawa Y, Saruta T (1998) Biophysical signals underlying myogenic responses in rat interlobular artery. Hypertension 32:1060–1065

    PubMed  CAS  Google Scholar 

  92. Tobin D, Madsen D, Kahn-Kirby A, Peckol E, Moulder G, Barstead R, Maricq A, Bargmann C (2002) Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Neuron 35:307–318

    PubMed  Article  CAS  Google Scholar 

  93. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531–543

    PubMed  Article  CAS  Google Scholar 

  94. Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP (1999) Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci USA 96:3934–3939

    PubMed  Article  CAS  Google Scholar 

  95. Tsiokas L, Kim S, Ong EC (2007) Cell biology of polycystin-2. Cell Signal 19:444–453

    PubMed  Article  CAS  Google Scholar 

  96. Vennekens R, Nilius B (2007) Insights into TRPM4 function, regulation and physiological role. Handb Exp Pharmacol 0:269–285

    Article  CAS  Google Scholar 

  97. Voets T, Nilius B (2003) TRPs make sense. J Membr Biol 192:1–8

    PubMed  Article  CAS  Google Scholar 

  98. Voets T, Talavera K, Owsianik G, Nilius B (2005) Sensing with TRP channels. Nat Chem Biol 1:85–92

    PubMed  Article  CAS  Google Scholar 

  99. Vriens J, Owsianik G, Fisslthaler B, Suzuki M, Janssens A, Voets T, Morisseau C, Hammock BD, Fleming I, Busse R, Nilius B (2005) Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res 97:908–915

    PubMed  Article  CAS  Google Scholar 

  100. Vriens J, Owsianik G, Voets T, Droogmans G, Nilius B (2004) Invertebrate TRP proteins as functional models for mammalian channels. Pflugers Arch 449:213–226

    PubMed  CAS  Google Scholar 

  101. Walker RG, Willingham AT, Zuker CS (2000) A Drosophila mechanosensory transduction channel. Science 287:2229–2234

    PubMed  Article  CAS  Google Scholar 

  102. Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B (2003) Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424:434–438

    PubMed  Article  CAS  Google Scholar 

  103. Welsh DG, Morielli AD, Nelson MT, Brayden JE (2002) Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 90:248–250

    PubMed  Article  CAS  Google Scholar 

  104. Wu Y, Dai XQ, Li Q, Chen CX, Mai W, Hussain Z, Long W, Montalbetti N, Li G, Glynne R, Wang S, Cantiello HF, Wu G, Chen XZ (2006) Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin. Hum Mol Genet 15:3280–3292

    PubMed  Article  CAS  Google Scholar 

  105. Yao X, Garland CJ (2005) Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res 97:853–863

    PubMed  Article  CAS  Google Scholar 

  106. Zhang Y, Gao F, Popov VL, Wen JW, Hamill OP (2000) Mechanically gated channel activity in cytoskeleton-deficient plasma membrane blebs and vesicles from Xenopus oocytes. J Physiol 523 Pt 1:117–130

    Google Scholar 

  107. Zhou XL, Batiza AF, Loukin SH, Palmer CP, Kung C, Saimi Y (2003) The transient receptor potential channel on the yeast vacuole is mechanosensitive. Proc Natl Acad Sci USA 100:7105–7110

    PubMed  Article  CAS  Google Scholar 

Download references

Acknowledgments

We are grateful to the ANR 2005 Cardiovasculaire-obésité-diabète, to the Association for Information and Research on Genetic Kidney Disease France, to the Fondation del Duca, to the Fondation de France, to the Fondation de la Recherche Médicale, to EEC Marie-Curie fellowships, to the Fondation de Recherche sur l’Hypertension Artérielle, to AFM, to INSERM, and to CNRS for support and Human Frontiers Science Program (HFSP Research Grant Ref. RGP 32/2004 BN and a long-term fellowship Ref. LT00555 to Dr. Sharif-Naeini), the Belgian Federal Government, the Flemish Government, the Onderzoeksraad KU Leuven (GOA 2004/07, F.W.O. G. 0136.00; F.W.O. G.0172.03, Interuniversity Poles of Attraction Program, Prime Ministers Office IUAP Nr.3P4/23, Excellentiefinanciering EF/95/010) to BN.

Author information

Affiliations

  1. Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR6097, 660 route des Lucioles, Sophia Antipolis, 06560, France

    Reza Sharif-Naeini, Alexandra Dedman, Joost H. A. Folgering, Fabrice Duprat, Amanda Patel & Eric Honoré

  2. KU Leuven, Department Mol Cell Biology, Laboratory Ion Channel Research, Campus Gasthuisberg, O&N 1, Herestraat 49-Bus 802, 3000, Leuven, Belgium

    Bernd Nilius

Authors
  1. Reza Sharif-Naeini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alexandra Dedman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joost H. A. Folgering
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fabrice Duprat
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Amanda Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bernd Nilius
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Eric Honoré
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eric Honoré.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sharif-Naeini, R., Dedman, A., Folgering, J.H.A. et al. TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch - Eur J Physiol 456, 529–540 (2008). https://doi.org/10.1007/s00424-007-0432-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00424-007-0432-y

Keywords

  • Blood vessel
  • Ca2 influx
  • Cerebral circulation
  • Cerebral artery
  • Channel gating
  • Channels
  • Mechanoreceptor
  • Mechanosensitivity
  • Mechano-electical transduction
  • Membrane current