Pflügers Archiv

, Volume 451, Issue 1, pp 181–192 | Cite as

TRPV5 and TRPV6 in Ca2+ (re)absorption: regulating Ca2+ entry at the gate

  • Tom Nijenhuis
  • Joost G. J. Hoenderop
  • René J. M. Bindels
Invited Review


Many physiological functions rely on the exact maintenance of body Ca2+ balance. Therefore, the extracellular Ca2+ concentration is tightly regulated by the concerted actions of intestinal Ca2+ absorption, exchange of Ca2+ to and from bone, and renal Ca2+ reabsorption. Renal distal convoluted and connecting tubular cells as well as duodenal epithelial cells are unique in their ability to mediate transcellular (re)absorption of Ca2+ at large and highly variable rates. Two members of the transient receptor potential (TRP) superfamily, TRP vanilloid (TRPV)5 and TRPV6, are specialized epithelial Ca2+ channels responsible for the critical Ca2+ entry step in transcellular Ca2+ (re)absorption in intestine and kidney, respectively. Because transcellular Ca2+ transport is fine-tuned to the body’s specific requirements, regulation of the transmembrane Ca2+ flux through TRPV5/6 is of particular importance and has, therefore, to be conspicuously controlled. We present an overview of the current knowledge and recent advances concerning the coordinated regulation of Ca2+ influx through the epithelial Ca2+ channels TRPV5 and TRPV6 in transcellular Ca2+ (re)absorption.


Calcium transport TRPV5 TRPV6 Regulation 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Tom Nijenhuis
    • 1
  • Joost G. J. Hoenderop
    • 1
  • René J. M. Bindels
    • 1
  1. 1.Department of Physiology, Nijmegen Centre for Molecular Life SciencesRadboud University Nijmegen Medical CentreHB NijmegenThe Netherlands

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