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Heartburn: cardiac potassium channels involved in parietal cell acid secretion

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Abstract

Hydrochloric acid is produced in parietal cells of the gastric glands by an H+/K+-ATPase. This proton pump couples the outwards movement of H+ to the inwards movement of K+ thus requiring the presence of luminal K+ to operate. To maintain the activity of the pump, K+ recirculates over the apical membrane via conductive pathways, the molecular nature of which has been identified in the past few years. This review gives a short overview about the recent advances in the understanding of the role of K+ channels in the process of parietal cell H+ secretion and focuses on the identification of KCNQ1/KCNE2 K+ channel as the molecular correlate of the parietal cell apical potassium conductance.

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Acknowledgements

The financial support by the DFG (WA 1088/3-1), the Kempkes foundation and Aventis is acknowledged.

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  1. Department of Paediatrics, University Hospital Marburg, Deutschhausstrasse 12, 35037, Marburg, Germany

    Siegfried Waldegger

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  1. Siegfried Waldegger
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Correspondence to Siegfried Waldegger.

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Waldegger, S. Heartburn: cardiac potassium channels involved in parietal cell acid secretion. Pflugers Arch - Eur J Physiol 446, 143–147 (2003). https://doi.org/10.1007/s00424-003-1048-5

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  • DOI: https://doi.org/10.1007/s00424-003-1048-5

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