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Molecular mechanisms of sepsis

  • REVIEW TOPIC: SEPSIS
  • Published:
Langenbeck's Archives of Surgery Aims and scope Submit manuscript

Abstract

Today a great number of problems in the field of bacterial sepsis remain to be solved. Understanding the molecular mechanisms of one of the most important bacterial products in the pathogenesis of sepsis – endotoxin – may contribute to innovative and more effective therapies. Therefore, this review focuses on the structural and functional elements of endotoxin, its interaction with immune cells, and its biological activity. Finally, other bacterial components and their impact on sepsis are discussed.

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Authors and Affiliations

  1. Research Center Borstel, Centre for Medicine and Biosciences, Parkallee 22, D-23845 Borstel, Germany Tel.: +45 37 188201; Fax: +45 37 188406; e-mail: erietschel@fz-borstel.de, , , , , , DE

    A. Woltmann, L. Hamann, A. J. Ulmer, J. Gerdes & E. T. Rietschel

  2. Department of Surgery, Medical University of Lübeck, D-23538 Lübeck, Germany, , , , , , DE

    H.-P. Bruch

Authors
  1. A. Woltmann
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  2. L. Hamann
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  3. A. J. Ulmer
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  4. J. Gerdes
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  5. H.-P. Bruch
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  6. E. T. Rietschel
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Received: 18 December 1997

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Woltmann, A., Hamann, L., Ulmer, A. et al. Molecular mechanisms of sepsis. Langenbeck's Arch Surg 383, 2–10 (1998). https://doi.org/10.1007/s004230050085

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  • DOI: https://doi.org/10.1007/s004230050085

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