Abstract
Despite advances in medical therapy, surgery continues to play a vital role in the management of Crohn’s disease and its complications. Continuing from Part I of this series (small intestine/ileal disease), we focus next on colonic Crohn’s disease and associated neoplasms. We will first review the surgical management of medical-refractory Crohn’s colitis and its complications and then examine cancer risk, surveillance, and surgical management of Crohn’s-associated colorectal dysplasia and malignancy. We conclude with a discussion of restoration of gastrointestinal continuity following colonic surgery for Crohn’s disease.
Similar content being viewed by others
References
Burisch J, Jess T, Martinato M et al (2013) The burden of inflammatory bowel disease in Europe. J Crohns Colitis 7(4):322–337
Dahlhamer JM, Zammitti EP, Ward BW et al (2016) Prevalence of inflammatory bowel disease among adults aged ≥18 years - United States, 2015. MMWR Morb Mortal Wkly Rep 65(42):1166–1169
Ng SC, Shi HY, Hamidi N et al (2017) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 390(10114):2769–2778
Kostic AD, Xavier RJ, Gevers D (2014) The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 146(6):1489–1499
Kavalukas SL, Scheurlen KM, Galandiuk S (2022) State-of-the-art surgery for Crohn’s disease: Part I-small intestine/ileal disease. Langenbecks Arch Surg 407:885–895
Gajendran M, Loganathan P, Catinella AP et al (2018) A comprehensive review and update on Crohn’s disease. Dis Mon 64(2):20–57
Shaffer VO, Wexner SD (2013) Surgical management of Crohn’s disease. Langenbecks Arch Surg 398(1):13–27
Mills S, Stamos MJ (2007) Colonic Crohn’s disease. Clin Colon Rectal Surg 20(4):309–313
Roberts H, Rai SN, Pan J et al (2014) Extraintestinal manifestations of inflammatory bowel disease and the influence of smoking. Digestion 90(2):122–129
Galandiuk S, Kimberling J, Al-Mishlab TG et al (2005) Perianal Crohn disease: predictors of need for permanent diversion. Ann Surg 241(5):796–801 (discussion 801–2)
Cho CW, You MW, Oh CH et al (2021) Long-term disease course of Crohn's disease: changes in disease location, phenotype, activities, and predictive factors. Gut Liver.
Lin SN, Zheng DP, Qiu Y et al (2020) Classifying Crohn’s disease into colon-involving versus non-colon-involving groups is a better predictor of clinical outcomes than the Montreal classification. Therap Adv Gastroenterol 13:1756284820968732
Autenrieth DM, Baumgart DC (2012) Toxic megacolon. Inflamm Bowel Dis 18(3):584–591
Øresland T, Bemelman WA, Sampietro GM et al (2015) European evidence based consensus on surgery for ulcerative colitis. J Crohns Colitis 9(1):4–25
Truelove SC, Witts LJ (1955) Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J 2(4947):1041–1048
Lightner AL, Vogel JD, Carmichael JC et al (2020) The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surgical Management of Crohn’s Disease. Dis Colon Rectum 63(8):1028–1052
Roberts SE, Williams JG, Yeates D et al (2007) Mortality in patients with and without colectomy admitted to hospital for ulcerative colitis and Crohn’s disease: record linkage studies. BMJ 335(7628):1033
Fornaro R, Caratto E, Caratto M et al (2015) Post-operative recurrence in Crohn’s disease. Critical analysis of potential risk factors. An update. Surgeon 13(6):330–47
Netz U, Galbraith NJ, O’Brien S et al (2018) Long-term outcomes following ileal pouch-anal anastomosis in patients with indeterminate colitis. Surgery 163(3):535–541
Silverberg MS, Satsangi J, Ahmad T et al (2005) Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 19 Suppl A:5a–36a
Sinagra E, Orlando A, Mocciaro F et al (2018) Clinical course of severe colitis: a comparison between Crohn’s disease and ulcerative colitis. J Biol Regul Homeost Agents 32(2):415–423
Dignass A, Lindsay JO, Sturm A et al (2012) Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management. J Crohns Colitis 6(10):991–1030
Brown SR, Fearnhead NS, Faiz OD et al (2018) The Association of Coloproctology of Great Britain and Ireland consensus guidelines in surgery for inflammatory bowel disease. Colorectal Dis 20(Suppl 8):3–117
Tapani MJ, Olavi KH (2014) Surgical Management of Toxic Megacolon. Hepatogastroenterology 61(131):638–641
Bemelman WA, Warusavitarne J, Sampietro GM et al (2018) ECCO-ESCP Consensus on Surgery for Crohn’s Disease. J Crohns Colitis 12(1):1–16
Tekkis PP, Purkayastha S, Lanitis S et al (2006) A comparison of segmental vs subtotal/total colectomy for colonic Crohn’s disease: a meta-analysis. Colorectal Dis 8(2):82–90
Angriman I, Pirozzolo G, Bardini R et al (2017) A systematic review of segmental vs subtotal colectomy and subtotal colectomy vs total proctocolectomy for colonic Crohn’s disease. Colorectal Dis 19(8):e279–e287
Goldberg HI, Caruthers SB Jr, Nelson JA et al (1979) Radiographic findings of the National Cooperative Crohn’s Disease Study. Gastroenterology 77(4 Pt 2):925–937
Yamazaki Y, Ribeiro MB, Sachar DB et al (1991) Malignant colorectal strictures in Crohn’s disease. Am J Gastroenterol 86(7):882–885
Fumery M, Yzet C, Chatelain D et al (2021) Colonic strictures in inflammatory bowel disease: epidemiology, complications, and management. J Crohns Colitis 15(10):1766–1773
Chang CW, Wong JM, Tung CC et al (2015) Intestinal stricture in Crohn’s disease. Intest Res 13(1):19–26
Kwon YH, Jeon SW, Lee YK (2013) Endoscopic management of refractory benign colorectal strictures. Clin Endosc 46(5):472–475
American Cancer Society. Cancer Statistics Center. Accessed Jan 8 2022]; Available from: http://cancerstatisticscenter.cancer.org.
Munkholm P (2003) Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease. Aliment Pharmacol Ther 18(Suppl 2):1–5
Basseri RJ, Basseri B, Vassilaki ME et al (2012) Colorectal cancer screening and surveillance in Crohn’s colitis. J Crohns Colitis 6(8):824–829
von Roon AC, Reese G, Teare J et al (2007) The risk of cancer in patients with Crohn’s disease. Dis Colon Rectum 50(6):839–855
Samadder NJ, Valentine JF, Guthery S et al (2019) Family history associates with increased risk of colorectal cancer in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 17(9):1807-1813.e1
Keller DS, Windsor A, Cohen R et al (2019) Colorectal cancer in inflammatory bowel disease: review of the evidence. Tech Coloproctol 23(1):3–13
Galandiuk S, Rodriguez-Justo M, Jeffery R et al (2012) Field cancerization in the intestinal epithelium of patients with Crohn’s ileocolitis. Gastroenterology 142(4):855-864.e8
Ullman T, Odze R, Farraye FA (2009) Diagnosis and management of dysplasia in patients with ulcerative colitis and Crohn’s disease of the colon. Inflamm Bowel Dis 15(4):630–638
Magro F, Gionchetti P, Eliakim R et al (2017) Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders. J Crohns Colitis 11(6):649–670
Murthy SK, Feuerstein JD, Nguyen GC et al (2021) AGA clinical practice update on endoscopic surveillance and management of colorectal dysplasia in inflammatory bowel diseases: expert review. Gastroenterology 161(3):1043-1051.e4
Laine L, Kaltenbach T, Barkun A et al (2015) SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastrointest Endosc 81(3):489-501.e26
Shergill AK, Lightdale JR, Bruining DH et al (2015) The role of endoscopy in inflammatory bowel disease. Gastrointest Endosc 81(5):1101-21.e1–13
Abraham BP (2016) Cancer surveillance in ulcerative colitis and Crohn’s disease: new strategies. Curr Opin Gastroenterol 32(1):32–37
Choi PM, Nugent FW, Schoetz DJ Jr et al (1993) Colonoscopic surveillance reduces mortality from colorectal cancer in ulcerative colitis. Gastroenterology 105(2):418–424
Lutgens MW, Oldenburg B, Siersema PD et al (2009) Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease. Br J Cancer 101(10):1671–1675
Bernstein CN, Blanchard JF, Kliewer E et al (2001) Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer 91(4):854–862
Murphy J, Kalkbrenner KA, Pemberton JH et al (2014) Dysplasia in ulcerative colitis as a predictor of unsuspected synchronous colorectal cancer. Dis Colon Rectum 57(8):993–998
Cremer A, Demetter P, De Vos M et al (2020) Risk of development of more-advanced lesions in patients with inflammatory bowel diseases and dysplasia. Clin Gastroenterol Hepatol 18(7):1528-1536.e5
Thomas T, Abrams KA, Robinson RJ et al (2007) Meta-analysis: cancer risk of low-grade dysplasia in chronic ulcerative colitis. Aliment Pharmacol Ther 25(6):657–668
Kiran RP, Nisar PJ, Goldblum JR et al (2012) Dysplasia associated with Crohn’s colitis: segmental colectomy or more extended resection? Ann Surg 256(2):221–226
Maser EA, Sachar DB, Kruse D et al (2013) High rates of metachronous colon cancer or dysplasia after segmental resection or subtotal colectomy in Crohn’s colitis. Inflamm Bowel Dis 19(9):1827–1832
Lightner AL, Vogler SA, Vaidya PS et al (2021) The fate of unifocal versus multifocal low-grade dysplasia at the time of colonoscopy in patients with IBD. Dis Colon Rectum 64(11):1364–1373
Sensi B, Khan J, Warusavitarne J et al (2021) Long-term oncological outcome of segmental versus extended colectomy for colorectal cancer in Crohn's disease: results from an international multicentre study. J Crohns Colitis.
Bogach J, Pond G, Eskicioglu C et al (2021) Extent of surgical resection in inflammatory bowel disease associated colorectal cancer: a population-based study. J Gastrointest Surg 25(10):2610–2618
Braveman JM, Schoetz DJ Jr, Marcello PW et al (2004) The fate of the ileal pouch in patients developing Crohn’s disease. Dis Colon Rectum 47(10):1613–1619
Deutsch AA, McLeod RS, Cullen J et al (1991) Results of the pelvic-pouch procedure in patients with Crohn’s disease. Dis Colon Rectum 34(6):475–477
Hercun J, Côté-Daigneault J, Lahaie RG et al (2021) Crohn’s disease after proctocolectomy and IPAA for ulcerative colitis. Dis Colon Rectum 64(2):217–224
Hyman NH, Fazio VW, Tuckson WB et al (1991) Consequences of ileal pouch-anal anastomosis for Crohn’s colitis. Dis Colon Rectum 34(8):653–657
Melton GB, Fazio VW, Kiran RP et al (2008) Long-term outcomes with ileal pouch-anal anastomosis and Crohn’s disease: pouch retention and implications of delayed diagnosis. Ann Surg 248(4):608–616
Tekkis PP, Heriot AG, Smith O et al (2005) Long-term outcomes of restorative proctocolectomy for Crohn’s disease and indeterminate colitis. Colorectal Dis 7(3):218–223
Lopez NE, Zaghyian K, Fleshner P (2019) Is there a role for ileal pouch anal anastomosis in Crohn’s disease? Clin Colon Rectal Surg 32(4):280–290
Le Q, Melmed G, Dubinsky M et al (2013) Surgical outcome of ileal pouch-anal anastomosis when used intentionally for well-defined Crohn’s disease. Inflamm Bowel Dis 19(1):30–36
Shen B, Patel S, Lian L (2010) Natural history of Crohn’s disease in patients who underwent intentional restorative proctocolectomy with ileal pouch-anal anastomosis. Aliment Pharmacol Ther 31(7):745–753
Panis Y, Poupard B, Nemeth J et al (1996) Ileal pouch/anal anastomosis for Crohn’s disease. Lancet 347(9005):854–857
Lightner AL, Jia X, Zaghiyan K et al (2021) IPAA in known preoperative Crohn’s disease: a systematic review. Dis Colon Rectum 64(3):355–364
Fazio VW, Kiran RP, Remzi FH et al (2013) Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients. Ann Surg 257(4):679–685
Author information
Authors and Affiliations
Contributions
AM and KMS performed initial literature review and manuscript preparation. SLK and SG reviewed and revised manuscript.
Corresponding author
Ethics declarations
Conflict of interest
Drs. Macleod, Kavalukas, and Scheurlen have no conflict of interest. Dr. Galandiuk is the Editor-in-Chief of the journal Diseases of the Colon and Rectum, is the Director of the Price Institute of Surgical Research, and receives support from AbbVie for clinical research.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Macleod, A., Kavalukas, S.L., Scheurlen, K.M. et al. State-of-the-art surgery for Crohn’s disease: Part II—colonic Crohn’s disease and associated neoplasms. Langenbecks Arch Surg 407, 2595–2605 (2022). https://doi.org/10.1007/s00423-022-02572-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00423-022-02572-y