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Laparoscopic liver resection for colorectal liver metastases: retrospective analysis of prognostic factors and oncological outcomes in a single-center cohort

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Abstract

Purpose

Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resection (OLR). The aim of this study was to determine prognostic factors for survival outcomes associated with LLR for CRLM.

Methods

A single-center retrospective analysis of a prospectively maintained database was performed. The inclusion period ranged from September 2011 until mid-March 2020.

Results

Two hundred consecutive LLRs were included. The 5-year overall survival (OS) and disease-free survival (DFS) rates equalled 54.8% and 49%, respectively. A pushing (HR = 5.42, 95% CI 1.56–18.88, p = 0.008), as well as a replacement (3.87, 1.05–14.2, p = 0.04) growth pattern of the CRLM, poor differentiation of the primary colorectal cancer (CRC) (3.72, 1.72–8.07, p < 0.001) and administration of neoadjuvant chemotherapy (NAC) (2.95, 1.28–6.8, p = 0.01) were identified as independent predictors of a worse OS. Requirement of more than 6 cycles of NAC (6.17, 2.37–16.03, p < 0.001), a replacement (4.96, 1.91–12.87, p < 0.001), as well as a pushing (4.3, 1.68–11, p = 0.002) growth pattern of the CRLM and poor differentiation of the primary CRC (2.61, 1.31–5.2, p = 0.006) were identified as independent predictors of a worse DFS.

Conclusion

LLR for CRLM offers adequate long-term oncologic outcomes. OS and DFS rates are negatively affected by the administration of NAC and by pathological features, including the differentiation grade of the primary CRC and the histological growth pattern of the CRLM.

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Authors and Affiliations

  1. Department of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital, President Kennedylaan 4, 8500, Kortrijk, Belgium

    Emily Taillieu, Celine De Meyere, Frederiek Nuytens & Mathieu D’Hondt

  2. Department of Pathological Anatomy, Groeninge Hospital, Kortrijk, Belgium

    Glenn Vanneste, Louis Libbrecht & Herwig Alaerts

  3. Department of Oncology and Statistics, Groeninge Hospital, Kortrijk, Belgium

    Isabelle Parmentier

  4. Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium

    Chris Verslype

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  1. Emily Taillieu
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Contributions

All of the authors meet the ICMJE authorship criteria with the following contributions specified: ET: study design, data acquisition and data interpretation. CDM: study design, data acquisition and data interpretation. FN: data interpretation. GV: data acquisition. LL: data acquisition and data interpretation. HA: data acquisition. IP: data acquisition. CV: study design and data interpretation. MD: study design and data interpretation.

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Correspondence to Mathieu D’Hondt.

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Taillieu, E., De Meyere, C., Nuytens, F. et al. Laparoscopic liver resection for colorectal liver metastases: retrospective analysis of prognostic factors and oncological outcomes in a single-center cohort. Langenbecks Arch Surg 407, 2399–2414 (2022). https://doi.org/10.1007/s00423-022-02534-4

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