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C-reactive protein to prealbumin ratio: a useful inflammatory and nutritional index for predicting prognosis after curative resection in esophageal squamous cell carcinoma patients

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Abstract

Purpose

Although C-reactive protein to prealbumin ratio (CPR) can predict the outcomes of several types of cancer surgeries, little is known about the implication of CPR in patients undergoing esophagectomy for esophageal squamous cell carcinoma (ESCC).

Methods

Between 2009 and 2018, 682 consecutive ESCC patients who underwent curative esophagectomy were enrolled. The clinicopathological factors and prognoses were compared between the groups stratified by preoperative CPR levels. A logistic regression model was used to determine the risk factors of postoperative pneumonia. Survival curves were constructed using the Kaplan–Meier method and compared using the log-rank test. The Cox proportional hazards model was used to elucidate prognostic factors.

Results

There were more elderly patients, more males, and more advanced clinical T and N categories in the high CPR group than in the low CPR group. Also, the incidence of postoperative pneumonia was significantly higher in the high CPR group than in the low CPR group (32.4% vs. 20.3%, p < 0.01). In multivariate analyses, high CPR was one of the independent predictive factors for postoperative pneumonia (OR, 1.71; 95% CI, 1.15–2.54; p < 0.03). Moreover, high CPR was an independent prognostic factor for overall, cancer-specific, and recurrence-free survivals (HR 1.62; 95% CI 1.18–2.23; p < 0.01, HR 1.57; 95% CI 1.08–2.32; p = 0.02, HR 1.42; 95% CI 1.06–1.90; p = 0.02).

Conclusion

Preoperative CPR was found to be a useful inflammatory and nutritional indicator for predicting the occurrence of pneumonia and prognosis in patients with ESCC undergoing esophagectomy.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto, Tokyo, 135-8550, Japan

    Suguru Maruyama, Akihiko Okamura, Yasukazu Kanie, Kei Sakamoto, Daisuke Fujiwara, Jun Kanamori, Yu Imamura, Koshi Kumagai & Masayuki Watanabe

  2. Department of Clinical Nutrition, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto, Tokyo, 135-8550, Japan

    Koshi Kumagai

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  1. Suguru Maruyama
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  2. Akihiko Okamura
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  3. Yasukazu Kanie
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Contributions

Study concept and design: MS, OA, and WM. Performance of operation: OA, KJ, IY, and WM. Draft the manuscript: MS, OA, and WM. Acquisition of data: MS, KY, SK, and FD. Analysis and interpretation of data: MS, OA, KK, and WM. All authors have revised and approved the manuscript.

Corresponding author

Correspondence to Akihiko Okamura.

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All study participants provided informed written consent prior to their study enrollment.

This study was approved by the institutional review board and performed under the ethical standards of the Declaration of Helsinki and its later amendments.

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The authors declare no competing interests.

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Maruyama, S., Okamura, A., Kanie, Y. et al. C-reactive protein to prealbumin ratio: a useful inflammatory and nutritional index for predicting prognosis after curative resection in esophageal squamous cell carcinoma patients. Langenbecks Arch Surg 407, 1901–1909 (2022). https://doi.org/10.1007/s00423-022-02508-6

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