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Fat signal fraction assessed with MRI predicts hepatic recurrence following hepatic resection for colorectal liver metastases

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Abstract

Purpose

The effect of hepatic steatosis on the development of colorectal liver metastases (CRLM) remains unknown. This study evaluated the usefulness of fat signal fraction assessed with magnetic resonance imaging (MRI) and the effect of hepatic steatosis on hepatic recurrences following initial hepatectomy for CRLM.

Methods

Between January 2013 and December 2019, 64 patients underwent initial hepatectomy for CRLM. The medical records of these patients were reviewed to evaluate the recurrence and survival outcomes.

Results

The fat signal fraction was positively correlated with the nonalcoholic fatty liver disease activity score and liver-spleen ratio. Recurrence following the initial hepatectomy was observed in 48/64 patients, and hepatic recurrence was observed in 30/64 patients. The fat signal fraction was significantly higher in patients with hepatic recurrence after initial hepatectomy. The hepatic recurrence rate was 69.2% in patients with fat signal fraction ≥ 0.0258, which was significantly higher than that in patients with fat signal fraction < 0.0258. Hepatic recurrence-free survival rate was significantly higher in patients with fat signal fraction < 0.0258 than in those with fat signal fraction ≥ 0.0258. Multivariate analyses revealed that fat signal fraction ≥ 0.0258 was an independent risk factor for hepatic recurrence.

Conclusion

The fat signal fraction assessed with MRI was significantly associated with hepatic recurrence following initial hepatectomy for CRLM.

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Data availability

The data that support the findings of the present study are available from the corresponding author upon reasonable request.

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Acknowledgements

We would like to thank Dr. Takuro Horikoshi, Department of Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, for the valuable advice regarding the MRI protocol.

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Authors and Affiliations

  1. Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan

    Nozomu Sakai, Takashi Mishima, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano & Masayuki Ohtsuka

  2. Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan

    Koichi Hayano & Hisahiro Matsubara

  3. Faculty of Nursing, Japanese Red Cross College of Nursing, Tokyo, Japan

    Yohei Kawasaki

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  1. Nozomu Sakai
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Correspondence to Masayuki Ohtsuka.

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Ethics approval

The retrospective study was performed in accordance with the principles of the Declaration of Helsinki. The study was approved by the Institutional Ethics Committee of the College of Medicine, Chiba University.

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Because of the retrospective nature of the study, informed consent was waived by the Institutional Ethics Committee of the College of Medicine, Chiba University. As an alternative, the opt-out consent was approved by the committee and obtained via our websites, where permission was requested for the use of the participants’ personal information in this study.

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The authors declare no competing interests.

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Sakai, N., Hayano, K., Mishima, T. et al. Fat signal fraction assessed with MRI predicts hepatic recurrence following hepatic resection for colorectal liver metastases. Langenbecks Arch Surg 407, 1981–1989 (2022). https://doi.org/10.1007/s00423-022-02482-z

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  • DOI: https://doi.org/10.1007/s00423-022-02482-z

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