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Impact of thyroidectomy on quality of life in benign goitres: results from a prospective cohort study

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Abstract

Purpose

Benign thyroid diseases encompass a large spectrum of conditions that are chronic and subtle in nature. A majority of patients choose non-surgical management and continue living their daily lives with subconscious impairment of optimal functioning. We studied the effect of thyroidectomy on the quality of life (QoL) in patients with benign goitres.

Methods

A prospective study was conducted on 50 patients between January 2017 and August 2018 using the ThyPRO 39 questionnaire. This is a disease-specific health-related questionnaire administered the day before surgery and 6 months following surgery. Data analysis was performed using EpiData Manager and EpiData Entry Client (v 3.1).

Results

The mean age of the cohort was 43.30 years ± 11.61, with a female preponderance (34:16). The most common indications for surgery were suspicion of malignancy and compressive symptoms in 34% and 30%, respectively. The most common histopathology reported was nodular/adenomatous hyperplasia (56%). Prior to surgery, the most common domains affected were emotional susceptibility and tiredness. Following surgery, a significant improvement in all domains of the ThyPRO 39 questionnaire were seen except for psychological well-being (p=0.126). In addition, the composite scores significantly improved (p<0.001). Younger age, female gender, and longer duration of goitre were the factors that significantly affected the outcomes in various domains.

Conclusion

Patients with benign goitres have subtle impairment of QoL which showed significant improvement following thyroidectomy.

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References

  1. Vanderpump MPJ (2011) The epidemiology of thyroid disease. Br Med Bull. 99(1):39–51

    Article  Google Scholar 

  2. Karthik KS, Suresh SS, Balakrishna MA, Ramesh DB (2015) Study of incidence of malignancy in clinically benign thyroid swelling. South Asian J Cancer. 4(3):151–153

    Article  CAS  Google Scholar 

  3. Christou N, Mathonnet M (2013) Complications after total thyroidectomy. J Visc Surg. 150(4):249–256

    Article  CAS  Google Scholar 

  4. Watt T, Groenvold M, Rasmussen ÅK, Bonnema SJ, Hegedüs L, Bjorner JB et al (2006) Quality of life in patients with benign thyroid disorders. A review. Eur J Endocrinol. 154(4):501–510

    Article  CAS  Google Scholar 

  5. Karimi M, Brazier J (2016) Health, health-related quality of life, and quality of life: what is the difference? PharmacoEconomics. 34(7):645–649

    Article  Google Scholar 

  6. Ware JE, Gandek B, Guyer R, Deng N Standardizing disease-specific quality of life measures across multiple chronic conditions: development and initial evaluation of the QOL Disease Impact Scale (QDIS®). Health Qual Life Outcomes [Internet]. 2016 Jun 2 [cited 2020 Nov 9];14. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890258/

  7. Li J, Zhang B, Bai Y, Liu Y, Zhang B, Jin J (2020) Health-related quality of life analysis in differentiated thyroid carcinoma patients after thyroidectomy. Sci Rep. 10(1):5765

    Article  CAS  Google Scholar 

  8. Bukvic B, Zivaljevic V, Sipetic S, Diklic A, Tausanovic K, Stojanovic D et al (2015) Improved quality of life in hyperthyroidism patients after surgery. J Surg Res. 193(2):724–730

    Article  Google Scholar 

  9. Watt T, Bjorner JB, Groenvold M, Cramon P, Winther KH, Hegedüs L et al (2015) Development of a short version of the thyroid-related patient-reported outcome ThyPRO. Thyroid. 25(10):1069–1079

    Article  Google Scholar 

  10. Bukvic BR, Zivaljevic VR, Sipetic SB, Diklic AD, Tausanovic KM, Paunovic IR (2014) Improvement of quality of life in patients with benign goiter after surgical treatment. Langenbecks Arch Surg. 399(6):755–764

    Article  Google Scholar 

  11. Mishra A, Sabaretnam M, Chand G, Agarwal G, Agarwal A, Verma AK et al (2013) Quality of life (QoL) in patients with benign thyroid goiters (pre- and post-thyroidectomy): a prospective study. World J Surg. 37(10):2322–2329

    Article  Google Scholar 

  12. Sorensen JR, Watt T, Cramon P, Døssing H, Hegedüs L, Bonnema SJ et al (2017) Quality of life after thyroidectomy in patients with nontoxic nodular goiter: a prospective cohort study. Head Neck. 39(11):2232–2240

    Article  Google Scholar 

  13. Zahan AE, Watt T, Pascanu I, Rasmussen AK, Hegedüs L, Bonnema SJ et al (2018) The Romanian version of the thyroid-related patient-reported outcomes ThyPRO and ThyPRO-39. Translation and Assessment of Reliability and Cross-cultural Validity. Acta Endocrinol Buchar. 14(2):192–200

    Article  CAS  Google Scholar 

  14. Watt T, Cramon P, Hegedüs L, Bjorner JB, Bonnema SJ, Rasmussen ÅK et al (2014) The thyroid-related quality of life measure ThyPRO has good responsiveness and ability to detect relevant treatment effects. J Clin Endocrinol Metab. 99(10):3708–3717

    Article  CAS  Google Scholar 

  15. N SC, Cherian AJ, Abraham DT, J PM. Transoral endoscopic thyroidectomy vestibular approach: early experience in a single centre. Int Surg J. 2019;6(6):2016–2021.

  16. Giusti M, Gay S, Conte L, Cecoli F, Mortara L, Vera L et al (2020) Evaluation of quality of life in patients with differentiated thyroid cancer by means of the thyroid-specific patient-reported outcome questionnaire: a 5-year longitudinal study. Eur Thyroid J. 9(5):247–255

    Article  Google Scholar 

  17. Gulseren S, Gulseren L, Hekimsoy Z, Cetinay P, Ozen C, Tokatlioglu B (2006 Jan) Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction. Arch Med Res. 37(1):133–139

    Article  Google Scholar 

  18. Zivaljevic VR, Bukvic Bacotic BR, Sipetic SB, Stanisavljevic DM, Maksimovic JM, Diklic AD et al (2015) Quality of life improvement in patients with Hashimoto thyroiditis and other goiters after surgery: a prospective cohort study. Int J Surg. 21:150–155

    Article  Google Scholar 

  19. Bartsch KD, Luster MJ, Buhr H, Lorenz D, Germer C-T, Goretzki EP (2018) Indications for the surgical management of benign goiter in adults. Dtsch Ärztebl Int. 115(1–2):1–7

    PubMed  Google Scholar 

  20. Watt T, Hegedüs L, Rasmussen AK, Groenvold M, Bonnema SJ, Bjorner JB et al (2007) Which domains of thyroid-related quality of life are most relevant? Patients and clinicians provide complementary perspectives. Thyroid Off J Am Thyroid Assoc. 17(7):647–654

    Article  Google Scholar 

  21. Sorensen JR (2018) The impact of surgery on quality of life, esophageal motility, and tracheal anatomy and airflow in patients with benign nodular goiter. Dan Med J 65(4)

  22. Dogan S, Sahbaz NA, Aksakal N, Tutal F, Torun BC, Yıldırım NK et al (2017) Quality of life after thyroid surgery. J Endocrinol Invest. 40(10):1085–1090

    Article  CAS  Google Scholar 

  23. Tabriz N, Uslar VN, Tabriz I, Weyhe D Quality of life is not affected by thyroid surgery in nontoxic benign goitre in long-term surveillance—a prospective observational study. Endocrinol Diabetes Metab [Internet]. 2020 Feb 26 [cited 2020 Nov 9];3(2). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170450/

  24. Promberger R, Hermann M, Pallikunnel SJ, Seemann R, Meusel M, Ott J (2014) Quality of life after thyroid surgery in women with benign euthyroid goiter: influencing factors including Hashimoto’s thyroiditis. Am J Surg. 207(6):974–979

    Article  Google Scholar 

  25. Knobel M Which Is the Ideal treatment for benign diffuse and multinodular non-toxic goiters? Front Endocrinol [Internet]. 2016 [cited 2020 Nov 9];7. Available from: https://www.frontiersin.org/articles/10.3389/fendo.2016.00048/full

  26. Papini E, Monpeyssen H, Frasoldati A, Hegedüs L (2020) 2020 European thyroid association clinical practice guideline for the use of image-guided ablation in benign thyroid nodules. Eur Thyroid J. 9(4):172–185

    Article  Google Scholar 

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Acknowledgements

We would like to thank the developer of the ThyPRO questionnaire, Torquil Watt, for permitting us to use the questionnaire in this study.

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Authors and Affiliations

  1. Department of General Surgery, Christian Medical College, Vellore, Tamil Nadu, 632004, India

    Swarna Azaria & Pranay Gaikwad

  2. Department of Endocrine Surgery, Christian Medical College, Vellore, Tamil Nadu, 632004, India

    Anish Jacob Cherian, Shawn Thomas, Paul MJ & Deepak Thomas Abraham

  3. Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, 632004, India

    Mahasampath Gowri

Authors
  1. Swarna Azaria
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  2. Anish Jacob Cherian
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  3. Mahasampath Gowri
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  4. Shawn Thomas
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  5. Pranay Gaikwad
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  6. Paul MJ
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  7. Deepak Thomas Abraham
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Contributions

SA participated in the study conception and design, acquisition of data, and drafting of manuscript. AJC participated in the drafting of manuscript, analysis and interpretation of data, and critical revision of manuscript. MGS participated in the analysis and interpretation of data. ST participated in the critical revision of manuscript. PG participated in the critical revision of manuscript. PMJ participated in the analysis and interpretation of data and critical revision of manuscript. DTA participated in the analysis and interpretation of data and critical revision of manuscript.

Corresponding author

Correspondence to Deepak Thomas Abraham.

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Azaria, S., Cherian, A.J., Gowri, M. et al. Impact of thyroidectomy on quality of life in benign goitres: results from a prospective cohort study. Langenbecks Arch Surg 407, 1193–1199 (2022). https://doi.org/10.1007/s00423-021-02391-7

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  • DOI: https://doi.org/10.1007/s00423-021-02391-7

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