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Influence of prognostic nutritional index and tumor markers on survival in gastric cancer surgery patients

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Abstract

Purpose

Blood analytes are easily used in routine clinical practice. Tumor markers (TMs) are useful in diagnosing, treating, and predicting prognosis of gastric cancer (GC). The prognostic nutritional index (PNI) was also recently found to be useful in predicting GC prognosis.

Methods

The PNI and serum levels of CEA and CA19-9 of 453 patients with GC were measured to examine correlations between those levels and patients’ prognoses.

Results

Of the 453 patients, 84 (18.5%) were positive for CEA and/or CA19-9 and therefore considered positive for TMs. Prognosis of patients who were TM+ was significantly worse than for those who were TM−. Mean PNI was 48.2 (range 27.7–63.6). ROC analysis indicated that 46.7 was the optimal PNI cutoff value. Prognosis of patients in the PNILow group (<46.7) was significantly worse than in the PNIHigh group (≥46.7). Prognosis of patients who were both TM+ and PNILow was significantly worse than that of patients who were either TM+ or PNILow and those who were both TM− and PNIHigh. Multivariate analysis indicated that combination of TM and PNI was an independent prognostic indicator.

Conclusions

The combination of TM and PNI offers accurate information about a patient’s prognosis.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan

    Hiroaki Saito, Yusuke Kono, Yuki Murakami, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto & Tomohiro Osaki

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  1. Hiroaki Saito
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  2. Yusuke Kono
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  3. Yuki Murakami
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  4. Hirohiko Kuroda
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  5. Tomoyuki Matsunaga
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  6. Yoji Fukumoto
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  7. Tomohiro Osaki
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Correspondence to Hiroaki Saito.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Saito, H., Kono, Y., Murakami, Y. et al. Influence of prognostic nutritional index and tumor markers on survival in gastric cancer surgery patients. Langenbecks Arch Surg 402, 501–507 (2017). https://doi.org/10.1007/s00423-017-1572-y

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  • DOI: https://doi.org/10.1007/s00423-017-1572-y

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