Skip to main content

Advertisement

SpringerLink
Log in

Postoperative peripheral blood monocyte count correlates with postoperative bile leakage in patients with colorectal liver metastases after hepatic resection

  • Original Article
  • Published:
Langenbeck's Archives of Surgery Aims and scope Submit manuscript

Abstract

Purpose

Postoperative bile leakage is one of the most common complications after hepatic surgery. The relationship between the inflammatory response and postoperative bile leakage has not been fully investigated. Therefore, we retrospectively investigated the relation between postoperative peripheral blood monocyte count and bile leakage in patients with colorectal liver metastases (CRLM) after elective hepatic resection.

Methods

The study comprised 105 patients who had undergone hepatic resection for CRLM between January 2000 and March 2012. Perioperative risk factors pertinent to development of bile leakage were investigated using univariate and multivariate analyses.

Results

Bile leakage developed in 9 (8.6 %) of 105 patients. In multivariate analysis, intraoperative fresh frozen plasma (FFP) transfusion (p = 0.009) and lower monocyte count of the peripheral blood on postoperative day 1 (p = 0.038) were found as independent risk factors of bile leakage.

Conclusions

Postoperative lower monocyte count and intraoperative FFP transfusion were associated with the development of postoperative bile leakage after elective hepatic resection in patients with CRLM.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH (1999) Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 230:309–318

    Article  PubMed  CAS  Google Scholar 

  2. Malik HZ, Prasad KR, Halazun KJ, Aldoori A, Al-Mukhtar A, Gomez D, Lodge JP, Toogood GJ (2007) Preoperative prognostic score for predicting survival after hepatic resection for colorectal liver metastases. Ann Surg 246:806–814

    Article  PubMed  Google Scholar 

  3. Simmonds PC, Primrose JN, Colquitt JL, Garden OJ, Poston GJ, Rees M (2006) Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer 94:982–999

    Article  PubMed  CAS  Google Scholar 

  4. Imamura H, Seyama Y, Kokudo N, Maema A, Sugawara Y, Sano K, Takayama T, Makuuchi M (2003) One thousand fifty-six hepatectomies without mortality in 8 years. Arch Surg 138:1198–1206

    Article  PubMed  Google Scholar 

  5. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, Corvera C, Weber S, Blumgart LH (2002) Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 236:397–406

    Article  PubMed  Google Scholar 

  6. Poon RT, Fan ST, Lo CM, Liu CL, Lam CM, Yuen WK, Yeung C, Wong J (2004) Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database. Ann Surg 240:698–708

    PubMed  Google Scholar 

  7. Yamashita Y, Hamatsu T, Rikimaru T, Tanaka S, Shirabe K, Shimada M, Sugimachi K (2001) Bile leakage after hepatic resection. Ann Surg 233:45–50

    Article  PubMed  CAS  Google Scholar 

  8. Capussotti L, Ferrero A, Viganò L, Sgotto E, Muratore A, Polastri R (2006) Bile leakage and liver resection: where is the risk? Arch Surg 141:690–694

    Article  PubMed  Google Scholar 

  9. Nagano Y, Togo S, Tanaka K, Masui H, Endo I, Sekido H, Nagahori K, Shimada H (2003) Risk factors and management of bile leakage after hepatic resection. World J Surg 27:695–698

    Article  PubMed  Google Scholar 

  10. Chatzipantelis P, Lazaris AC, Kafiri G, Nonni A, Papadimitriou K, Xiromeritis K, Patsouris ES (2008) CD56 as a useful marker in the regenerative process of the histological progression of primary biliary cirrhosis. Eur J Gastroenterol Hepatol 20:837–842

    Article  PubMed  CAS  Google Scholar 

  11. Armbrust T, Batusic D, Xia L, Ramadori G (2002) Early gene expression of hepatocyte growth factor in mononuclear phagocytes of rat liver after administration of carbon tetrachloride. Liver 22:486–494

    Article  PubMed  CAS  Google Scholar 

  12. Miyagawa S, Makuuchi M, Kawasaki S, Kakazu T (1995) Criteria for safe hepatic resection. Am J Surg 169:589–594

    Article  PubMed  CAS  Google Scholar 

  13. Strasberg SM (2005) Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system. J Hepatobiliary Pancreat Surg 12:351–355

    Article  PubMed  Google Scholar 

  14. Japanese Bureau of Medical Safety, Ministry of Health and Welfare (1999) Guidelines for administering blood preparations. Medical and Pharmaceutical Notification No. 715, 10 June 1999.

  15. Lo CM, Fan ST, Liu CL, Lai EC, Wong J (1998) Biliary complications after hepatic resection: risk factors, management, and outcome. Arch Surg 133:156–161

    Article  PubMed  CAS  Google Scholar 

  16. Gruttadauria S, Saint Georges Chaumet M, Pagano D, Marsh JW, Bartoccelli C, Cintorino D, Arcadipane A, Vizzini G, Spada M, Gridelli B (2011) Impact of blood transfusion on early outcome of liver resection for colorectal hepatic metastases. J Surg Oncol 103:140–147

    Article  PubMed  Google Scholar 

  17. Schneider SO, Rensing H, Gräber S, Kreuer S, Kleinschmidt S, Kreimeier S, Müller P, Mathes AM, Biedler AE (2009) Impact of platelets and fresh frozen plasma in contrast to red cell concentrate on unstimulated and stimulated cytokine release in an in vitro model of transfusion. Scand J Immunol 70:101–105

    Article  PubMed  CAS  Google Scholar 

  18. Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, Taub R (1996) Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274:1379–1383

    Article  PubMed  CAS  Google Scholar 

  19. Haruki K, Shiba H, Fujiwara Y, Furukawa K, Wakiyama S, Ogawa M, Ishida Y, Misawa T, Yanaga K (2012) Perioperative change in peripheral blood monocyte count may predict prognosis in patients with colorectal liver metastasis after hepatic resection. J Surg Oncol 106:31–35

    Article  PubMed  Google Scholar 

  20. Ren X, Hu B, Colletti L (2008) Stem cell factor and its receptor, c-kit, are important for hepatocyte proliferation in wild-type and tumor necrosis factor receptor-1 knockout mice after 70% hepatectomy. Surgery 143:790–802

    Article  PubMed  Google Scholar 

  21. Amemiya H, Kono H, Fujii H (2011) Liver regeneration is impaired in macrophage colony stimulating factor deficient mice after partial hepatectomy: the role of M-CSF-induced macrophages. J Surg Res 165:59–67

    Article  PubMed  CAS  Google Scholar 

  22. Meng F, Francis H, Glaser S, Han Y, DeMorrow S, Stokes A, Staloch D, Venter J, White M, Ueno Y, Reid LM, Alpini G (2012) Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration. Hepatology 55:209–221

    Article  PubMed  CAS  Google Scholar 

  23. Lederer A, Seehofer D, Schirmeier A, Levasseur S, Stockmann M, Nüssler AK, Menger MD, Neuhaus P, Rayes N (2013) Postoperative bile leakage inhibits liver regeneration after 70% hepatectomy in rats. J Invest Surg 26:35–45

    Article  Google Scholar 

  24. Seehofer D, Stockmann M, Schirmeier A, Nüssler AK, Cho SY, Rayes N, Koch M, Schiller R, Menger MD, Neuhaus P (2007) Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy. Langenbecks Arch Surg 392:273–284

    Article  PubMed  Google Scholar 

Download references

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan

    Koichiro Haruki, Hiroaki Shiba, Yuki Fujiwara, Kenei Furukawa, Shigeki Wakiyama, Masaichi Ogawa, Yuichi Ishida, Takeyuki Misawa & Katsuhiko Yanaga

Authors
  1. Koichiro Haruki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroaki Shiba
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuki Fujiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kenei Furukawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shigeki Wakiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masaichi Ogawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yuichi Ishida
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Takeyuki Misawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Katsuhiko Yanaga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Koichiro Haruki.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haruki, K., Shiba, H., Fujiwara, Y. et al. Postoperative peripheral blood monocyte count correlates with postoperative bile leakage in patients with colorectal liver metastases after hepatic resection. Langenbecks Arch Surg 398, 851–855 (2013). https://doi.org/10.1007/s00423-013-1083-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00423-013-1083-4

Keywords

Search

Navigation