Abstract
Purpose
Peritoneal recurrence of ovarian cancer is frequent after primary surgery and chemotherapy and has poor long-term survival. De novo cytoreductive surgery is crucial with the potential to improve prognosis, especially when combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
Methods
The sampled data of 40 consecutive patients were retrospectively analyzed. Thirty-one patients were treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy.
Results
No patient was lost in the perioperative period, and the combined procedure was performed with acceptable morbidity. Colon-preserving cytoreductive surgery was associated with reduced morbidity.
Conclusions
Patients suffering from peritoneal recurrence of ovarian cancer should be considered for radical reoperation with HIPEC in a center with expertise in multimodal therapeutic options. Organ-preserving cytoreductive surgery allows complete cytoreduction with the goal of decreasing morbidity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Di Giorgio A, Naticchioni E, Biacchi D, Sibio S, Accarpio F, Rocco M, Tarquini S, Di Seri M, Ciardi A, Montruccoli D, Sammartino P (2008) Cytoreductive surgery (peritonectomy procedures) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of diffuse peritoneal carcinomatosis from ovarian cancer. Cancer 113:315–325
Bijelic L, Jonson A, Sugarbaker PH (2007) Systematic review of cytoreductive surgery and heated intraoperative intraperitoneal chemotherapy for treatment of peritoneal carcinomatosis in primary and recurrent ovarian cancer. Ann Oncol 18:1943–1950
Chua TC, Robertson G, Liauw W, Farrell R, Yan TD, Morris DL (2009) Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery in ovarian cancer peritoneal carcinomatosis: systematic review of current results. J Cancer Res Clin Oncol 135:1637–1645
Königsrainer I, Aschoff P, Zieker D, Beckert S, Glatzle J, Pfannenberg C, Miller S, Hartmann JT, Schroeder TH, Brücher BL, Königsrainer A (2008) Selection criteria for peritonectomy with hyperthermic intraoperative chemotherapy (HIPEC) in peritoneal carcinomatosis. Zentralbl Chir 133:468–472
Jacquet P, Sugarbaker PH (1996) Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis. Cancer Treat Res 82:359–374
Stephens AD, Alderman R, Chang D, Edwards GD, Esquivel J, Sebbag G, Steves MA, Sugarbaker PH (1999) Morbidity and mortality analysis of 200 treatments with cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy using the coliseum technique. Ann Surg Oncol 6:790–796
Sugarbaker PH (1996) Complete parietal and visceral peritonectomy of the pelvis for advanced primary and recurrent ovarian cancer. Cancer Treat Res 81:75–87
Königsrainer I, Zieker D, Beckert S, von Weyhern C, Löb S, Falch C, Brücher BL, Königsrainer A, Glatzle J (2009) Local peritonectomy highly attracts free floating intraperitoneal colorectal tumour cells in a rat model. Cell Physiol Biochem 23(4–6):371–378
Jacquet P, Elias D, Sugarbaker PH (1996) Tumor implantation in cicatrization sites following surgery for digestive cancers. J Chir (Paris) 133:175–182
Conflicts of interest
None.
Author information
Authors and Affiliations
Corresponding author
Additional information
This manuscript contains original material that has not been previously published.
Rights and permissions
About this article
Cite this article
Königsrainer, I., Beckert, S., Becker, S. et al. Cytoreductive surgery and HIPEC in peritoneal recurrent ovarian cancer: experience and lessons learned. Langenbecks Arch Surg 396, 1077–1081 (2011). https://doi.org/10.1007/s00423-011-0835-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00423-011-0835-2