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Extended lymphadenectomy improvement of overall survival of gastric cancer patients with perigastric node metastasis

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Abstract

Background

The superiority of extended lymphadenectomy for the prognosis of gastric cancer (GC) is still controversial. The authors hypothesized that extended lymphadenectomy could improve the overall survival (OS) of GC patients with a specific extent of lymph node metastasis.

Methods

Data from 456 GC patients who underwent curative gastrectomy with lymphadenectomy were used to illuminate the difference of OS between patients who underwent limited lymphadenectomy and patients who underwent extended lymphadenectomy.

Results

As a whole, there was no significant difference of OS between patients who underwent extended lymphadenectomy and patients who underwent limited lymphadenectomy in all 456 GC patients. However, we demonstrated that extended lymphadenectomy significantly improved the OS of GC patients with perigastric lymph node metastasis (n1 stage based on the Japanese Gastric Cancer Association classification) compared to limited lymphadenectomy (P = 0.023). Furthermore, the more the negative lymph nodes were, the longer the OS of GC patients with perigastric node metastasis following extended lymphadenectomy was (P < 0.001).

Conclusions

Extensive lymph node dissection and good harvest of negative lymph nodes should be deemed as the most important factors to improve the OS of GC patients with perigastric node metastasis.

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Acknowledgment

This study was supported in part by grants from the National Basic Research Program of China (973 Program) 2010CB529301.

Conflicts of interest

None.

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Authors and Affiliations

  1. Department of Gastric Cancer Surgery, Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer Center, Tianjin, China

    Jingyu Deng, Han Liang & Yong Liu

  2. Institute of Lung Cancer, Tianjin Medical University General Hospital, Tianjin, China

    Dan Sun

  3. Department of Pathology, Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer Center, Tianjin, China

    Yi Pan

  4. Department of Hepatobiliary Cancer Surgery, Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer Center, Tianjin, China

    Dianchang Wang

Authors
  1. Jingyu Deng
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  2. Han Liang
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  5. Yong Liu
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Correspondence to Han Liang.

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Deng, J., Liang, H., Sun, D. et al. Extended lymphadenectomy improvement of overall survival of gastric cancer patients with perigastric node metastasis. Langenbecks Arch Surg 396, 615–623 (2011). https://doi.org/10.1007/s00423-011-0753-3

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  • DOI: https://doi.org/10.1007/s00423-011-0753-3

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