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Preoperative cholangitis independently increases in-hospital mortality after combined major hepatic and bile duct resection for hilar cholangiocarcinoma

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Abstract

Purpose

This study evaluated the impact of ductal bile bacteria (bactibilia or cholangitis) on the development of surgical site infection (SSI) or in-hospital mortality after resection for hilar cholangiocarcinoma.

Materials and methods

A retrospective analysis was conducted on 81 patients who underwent a combined major hepatic (hemihepatectomy or more extensive hepatectomy) and bile duct resection for hilar cholangiocarcinoma. Ductal bile was submitted for bacterial culture before or during the operation.

Results

The incidence of SSI was higher in patients with preoperative bactibilia (83%) than in patients without (52%; P = 0.008). Preoperative bactibilia was an independent variable associated with SSI (relative risk 9.003; P = 0.002). The incidence of in-hospital mortality was higher in patients with preoperative cholangitis (33%) than in patients without (6%; P = 0.009). Preoperative cholangitis was the only independent variable associated with in-hospital mortality (relative risk 9.115; P = 0.006).

Conclusions

Preoperative cholangitis independently increases in-hospital mortality after combined major hepatic and bile duct resection for hilar cholangiocarcinoma, whereas preoperative bactibilia independently increases SSI.

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Authors and Affiliations

  1. Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan

    Jun Sakata, Yoshio Shirai, Toshifumi Wakai & Katsuyoshi Hatakeyama

  2. Department of Surgery, Niigata Cancer Center Hospital, 2-15-3 Kawagishi-cho, Chuo-ku, Niigata, 951-8566, Japan

    Yoshiaki Tsuchiya & Tatsuya Nomura

Authors
  1. Jun Sakata
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  2. Yoshio Shirai
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  3. Yoshiaki Tsuchiya
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  4. Toshifumi Wakai
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  5. Tatsuya Nomura
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  6. Katsuyoshi Hatakeyama
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Corresponding author

Correspondence to Yoshio Shirai.

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Sakata, J., Shirai, Y., Tsuchiya, Y. et al. Preoperative cholangitis independently increases in-hospital mortality after combined major hepatic and bile duct resection for hilar cholangiocarcinoma. Langenbecks Arch Surg 394, 1065–1072 (2009). https://doi.org/10.1007/s00423-009-0464-1

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  • DOI: https://doi.org/10.1007/s00423-009-0464-1

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